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Merck

ABCC2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Sinonimi:
ABC30, CMOAT, DJS, MRP2, cMRP
Specie:
Human ABCC2 (1244), Mouse Abcc2 (12780), Rat Abcc2 (25303), sheep ABCC2 (101119776), Horse ABCC2 (100060654), naked mole-rat Abcc2 (101716089), domestic guinea pig Abcc2 (100718828), cow ABCC2 (520925), domestic cat ABCC2 (101085924), dog ABCC2 (403632) ...Più
ID UniProtKB:
Q92887, B2RMT8, Q14022, Q5T2B1, Q92500, Q92798, Q99663, Q9UMS2
ID gene:
  • Human(1244) Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
  • Mouse(12780) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Rat(25303) ATP-binding cassette, subfamily C (CFTR/MRP), member 2
  • sheep(101119776) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Horse(100060654) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • naked mole-rat(101716089) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • domestic guinea pig(100718828) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • cow(520925) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • domestic cat(101085924) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • dog(403632) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • chicken(423828) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Zebrafish(393561) ATP-binding cassette, sub-family C (CFTR/MRP), member 2

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Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
M3692
Anti-MRP2 antibody, Mouse monoclonal, clone CPR96, purified from hybridoma cell culture,
Reattività con
human
Applicazione
ELISA
microarray
western blot
ZRB2029
Anti-MRP2 Antibody, clone 1B2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human, monkey
Applicazione
affinity binding assay
flow cytometry
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
MABN1545
Anti-MRP2 Antibody, clone 4C9.2, clone 4C9.2, from mouse,
Reattività con
human
Applicazione
immunohistochemistry
western blot
MAB4148
Anticorpo anti-MRP2, clone M2 I-4, culture supernatant, clone M2 I-4, Chemicon®,
Reattività con
human
Applicazione
immunocytochemistry
immunohistochemistry
western blot
SAB1403681
Monoclonal Anti-ABCC2 antibody produced in mouse, clone 2H6, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
immunofluorescence
western blot

Kits

Numero di prodotto
Descrizione
Specie
MAK161
Multidrug Resistance Assay Kit, (Fluorometric MDR Assay),
Specie
human, mouse, rat

esiRNA

Numero di prodotto
Descrizione
Specie
EHU052041
MISSION® esiRNA, targeting human ABCC2,
Specie
human