POMC
proopiomelanocortin
Sinonimi:
ACTH, CLIP, LPH, MSH, NPP, POC
Specie:
Human POMC (5443), Mouse Pomc (18976), Rat Pomc (24664), cow POMC (281416), domestic guinea pig Pomc (100720803), chicken POMC (422011), naked mole-rat Pomc (101718053), Goat POMC (100861398), Horse POMC (100071524), domestic cat POMC (101087223) ...Più
ID UniProtKB:
ID gene:
- Human(5443) Summary: This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
- Mouse(18976) pro-opiomelanocortin-alpha
- Rat(24664) proopiomelanocortin
- cow(281416) proopiomelanocortin
- domestic guinea pig(100720803) proopiomelanocortin
- chicken(422011) proopiomelanocortin
- naked mole-rat(101718053) proopiomelanocortin
- Goat(100861398) proopiomelanocortin
- Horse(100071524) proopiomelanocortin
- domestic cat(101087223) proopiomelanocortin
- sheep(443212) proopiomelanocortin
- dog(403659) proopiomelanocortin
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Antibodies
Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-Melanocyte Stimulating Hormone α Antibody, serum, Chemicon®,
Reattività con
mammals
Applicazione
immunohistochemistry
radioimmunoassay
radioimmunoassay
Anti-Proopiomelanocortin/POMC antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-α-MSH antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
microarray
microarray
Anti-Endorphin β Antibody, clone 3-E7, clone 3-E7, Chemicon®, from mouse,
Reattività con
human, pig
Applicazione
ELISA
immunohistochemistry
immunohistochemistry
Anti-POMC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunohistochemistry
Proteins
Numero di prodotto
Descrizione
Specie
[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt, ≥95% (HPLC),
Specie
human