116765

Adenosine A _2A/A₁ Receptor Antagonist

The Adenosine A_2A/A₁ Receptor Antagonist controls the biological activity of Adenosine A_2A/A₁ Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Sinonimo/i: Adenosine A _2A/A₁ Receptor Antagonist
• Formula empirica (notazione di Hill): C₂₃H₂₂N₄O₃ · 2HCl
• Numero CAS: 1309358-54-0
• Peso molecolare: 475.37
• UNSPSC Code: 12352200
• MDL number: MFCD18800878

Proprietà

• Nome del prodotto: Adenosine A _2A/A₁ Receptor Antagonist, The Adenosine A_2A/A₁ Receptor Antagonist controls the biological activity of Adenosine A_2A/A₁ Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications.
• SMILES string: NC(N=C1C2=CC=CC=C2)=NC(C3=C4C=CC(OCCN5CCOCC5)=C3)=C1C4=O
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: light yellow
• solubility: DMSO: 10 mg/mL, clear, yellow
• shipped in: ambient
• storage temp.: 2-8°C
• Quality Level: 100

Descrizione

Disclaimer

Toxicity: Standard Handling (A)

General description

A blood-brain barrier-permeant indenopyrimidinone that acts as a dual A₁/A_2A antagonist (K_i = 48.2 and 6.5 nM, respectively, against agonist-induced cAMP response in A₁- or A_2A-expressing CHO-K1 cells) and effectively reverses D₂ antagonist haloperidol- (1 mg/kg; s.c.) induced catalepsy in both rats and mice (ED₅₀ = 0.3 and <0.1 mg/kg, respectively) in vivo by simultaneously reversing A₁-mediated inhibition of DA (Dopamine) release and A_2A-dependent inhibition of D₂ receptor response to DA.

The Adenosine A_2A/A₁ Receptor Antagonist controls the biological activity of Adenosine A_2A/A₁ Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications.

Other Notes

Shook, B.C., et al. 2012. J. Med. Chem.55, 1402.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable