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890895P

Avanti

18:1 TAP (DOTAP, MS Salt)

Avanti Polar Lipids 890895P, powder

Synonym(s):
1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt)
Empirical Formula (Hill Notation):
C43H83NO8S
CAS Number:
Molecular Weight:
774.19
NACRES:
NA.25

form

powder

packaging

pkg of 2 × 100 mg (890895P-200mg)
pkg of 1 × 25 mg (890895P-25mg)

manufacturer/tradename

Avanti Polar Lipids 890895P

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.O=S([O-])(OC)=O

InChI

1S/C42H80NO4.CH4O4S/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;1-5-6(2,3)4/h20-23,40H,6-19,24-39H2,1-5H3;1H3,(H,2,3,4)/q+1;/p-1/b22-20-,23-21-;

InChI key

RSMRWWHFJMENJH-LQDDAWAPSA-M

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18:1 TAP (DOTAP, MS Salt) Avanti Polar Lipids 890895P, powder

Avanti

890895P

18:1 TAP (DOTAP, MS Salt)

18:1 TAP (DOTAP, MS Salt) Avanti Polar Lipids 890895C

Avanti

890895C

18:1 TAP (DOTAP, MS Salt)

18:1 TAP (DOTAP) Avanti Polar Lipids

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18:0 TAP Avanti Polar Lipids 890880P, powder

Avanti

890880P

18:0 TAP

packaging

pkg of 2 × 100 mg (890895P-200mg), pkg of 1 × 25 mg (890895P-25mg)

packaging

pkg of 1 × 2.5 mL (890895C-25mg), pkg of 2 × 4 mL (890895C-200mg)

packaging

pkg of 1 × 1 g ((890890P-1G)), pkg of 2 × 100 mg ((890890P-200MG)), pkg of 5 × 100 mg ((890890P-100MG)), pkg of 1 × 25 mg ((890890P-25MG))

packaging

pkg of 1 × 200 mg (890880P-200mg), pkg of 1 × 25 mg (890880P-25mg)

manufacturer/tradename

Avanti Polar Lipids 890895P

manufacturer/tradename

Avanti Polar Lipids 890895C

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids 890880P

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

lipid type

cationic lipids
transfection

lipid type

cationic lipids
transfection

lipid type

transfection
cationic lipids

lipid type

cationic lipids
transfection

Biochem/physiol Actions

1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) is a cationic lipid, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP. DOTAP mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Packaging

5 mL Clear Glass Sealed Ampule (890895P-200mg)
5 mL Clear Glass Sealed Ampule (890895P-25mg)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Cholesterol Sigma Grade, ≥99%

Sigma-Aldrich

C8667

Cholesterol

Sodium deoxycholate ≥97% (titration)

Sigma-Aldrich

D6750

Sodium deoxycholate

Sabata Martino et al.
Journal of biomedicine & biotechnology, 2009, 410260-410260 (2009-06-09)
RNA interference technology is an ideal strategy to elucidate the mechanisms associated with human CD34(+) hematopoietic stem cell differentiation into dendritic cells. Simple manipulations in vitro can unequivocally yield alloreactive or tolerogenic populations, suggesting key implications of biochemical players that
Dmitri Simberg et al.
Critical reviews in therapeutic drug carrier systems, 21(4), 257-317 (2005-01-11)
Cationic lipid-mediated nucleic acid and protein delivery is becoming increasingly popular for in vitro and in vivo applications. While the chemistry of cationic lipid carriers is moving very rapidly, and more and more sophisticated molecules are being developed, it is
Bieong-Kil Kim et al.
Biochimica et biophysica acta, 1848(10 Pt A), 1996-2001 (2015-06-27)
The effects of lipid compositions on their physicochemical properties and transfection efficiencies were investigated. Four liposome formulations with different 1,2-dioleoyl-3-trimethylammoniumpropane (DOTAP) to dioleoylphosphatidylethanolamine (DOPE) weight ratios were investigated, that is, weight ratios 1:0 (T1P0), 3:1 (T3P1), 1:1 (T1P1), and 1:3

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