Merck
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890900O

Avanti

ALC-0315

Avanti Polar Lipids

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Synonym(s):
ALC 0315, 6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-aminium
Empirical Formula (Hill Notation):
C48H95NO5
Molecular Weight:
766.27

form

oil

packaging

pkg of 1x1 g (890900O-1G)
pkg of 1x100 mg (890900O-100MG)
pkg of 1x200 mg (890900O-200MG)
pkg of 1x25 mg (890900O-25MG)
pkg of 1x50 mg (890900O-50MG)
pkg of 1x500 mg (890900O-500MG)

manufacturer/tradename

Avanti Polar Lipids

technique(s)

thin layer chromatography (TLC): suitable

application(s)

advanced drug delivery

lipid type

cationic lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(C(CCCCCC)CCCCCCCC)OCCCCCCN(CCCCO)CCCCCCOC(C(CCCCCCCC)CCCCCC)=O

Application


  • Cationic Lipid Pairs Enhance Liver-to-Lung Tropism of Lipid Nanoparticles for In Vivo mRNA Delivery.: ALC-0315 plays a critical role in this study, enhancing the delivery efficiency of mRNA therapies from liver to lung. This research could lead to improved treatment options for various pulmonary diseases (Zeng et al., 2024).

  • Engineering LNPs with polysarcosine lipids for mRNA delivery.: Demonstrates ALC-0315′s application in designing lipid nanoparticles that efficiently deliver mRNA, showcasing potential advancements in gene therapy (Kang et al., 2024).

  • Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy.: Utilizes ALC-0315 in the development of lipid nanoparticles that activate under tumor-specific conditions to deliver immunotherapeutic agents, offering a targeted approach to cancer treatment (Jiang et al., 2024).

Packaging

  • 5 mL Amber Glass Screw Cap Vial (890900O-25MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-50MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-100MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-200MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-500MG)
  • 30 mL Amber Glass Screw Cap Vial(890900O-1G)

Other Notes

Quantities limited to 50G in a calendar year per customer.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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