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890900O

Avanti

ALC-0315

Avanti Research™ - A Croda Brand

Synonym(s):

ALC 0315, 6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-aminium

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About This Item

Empirical Formula (Hill Notation):
C48H95NO5
Molecular Weight:
766.27
MDL number:
MFCD33402175
UNSPSC Code:
12352211
NACRES:
NA.25
Pricing and availability is not currently available.

form

oil

packaging

pkg of 1x1 g (890900O-1G)
pkg of 1x100 mg (890900O-100MG)
pkg of 1x200 mg (890900O-200MG)
pkg of 1x25 mg (890900O-25MG)
pkg of 1x50 mg (890900O-50MG)
pkg of 1x500 mg (890900O-500MG)

manufacturer/tradename

Avanti Research™ - A Croda Brand

technique(s)

thin layer chromatography (TLC): suitable

application(s)

advanced drug delivery

lipid type

cationic lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(C(CCCCCC)CCCCCCCC)OCCCCCCN(CCCCO)CCCCCCOC(C(CCCCCCCC)CCCCCC)=O

InChI

1S/C48H95NO5/c1-5-9-13-17-19-27-37-45(35-25-15-11-7-3)47(51)53-43-33-23-21-29-39-49(41-31-32-42-50)40-30-22-24-34-44-54-48(52)46(36-26-16-12-8-4)38-28-20-18-14-10-6-2/h45-46,50H,5-44H2,1-4H3

InChI key

QGWBEETXHOVFQS-UHFFFAOYSA-N

Application


  • Cationic Lipid Pairs Enhance Liver-to-Lung Tropism of Lipid Nanoparticles for In Vivo mRNA Delivery.: ALC-0315 plays a critical role in this study, enhancing the delivery efficiency of mRNA therapies from liver to lung. This research could lead to improved treatment options for various pulmonary diseases (Zeng et al., 2024).

  • Engineering LNPs with polysarcosine lipids for mRNA delivery.: Demonstrates ALC-0315′s application in designing lipid nanoparticles that efficiently deliver mRNA, showcasing potential advancements in gene therapy (Kang et al., 2024).

  • Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy.: Utilizes ALC-0315 in the development of lipid nanoparticles that activate under tumor-specific conditions to deliver immunotherapeutic agents, offering a targeted approach to cancer treatment (Jiang et al., 2024).

Packaging

  • 5 mL Amber Glass Screw Cap Vial (890900O-25MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-50MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-100MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-200MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-500MG)
  • 30 mL Amber Glass Screw Cap Vial(890900O-1G)

Other Notes

Quantities limited to 50G in a calendar year per customer.

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

890900O-100MG:
890900O-1G:
890900O-25MG:
890900O-200MG:
890900O-VAR:
890900O-500MG:
890900O-50MG:

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Certificates of Analysis (COA)

Lot/Batch Number

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