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Merck

1.06345

Sodium dihydrogen phosphate dihydrate

EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JPE, USP, E 339

Synonym(s):

Sodium phosphate monobasic dihydrate, mono-Sodium orthophosphate, Sodium biphosphate, Sodium phosphate monobasic, Sodium dihydrogen phosphate dihydrate

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About This Item

Linear Formula:
NaH2PO4 · 2H2O
CAS Number:
13472-35-0
Molecular Weight:
156.01
EC Index Number:
231-449-2
E Number:
E339
UNSPSC Code:
12352302
MDL number:
MFCD00149209

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InChI

1S/Na.H3O4P.2H2O/c;1-5(2,3)4;;/h;(H3,1,2,3,4);2*1H2/q+1;;;/p-1

SMILES string

O.O.[Na+].OP(O)([O-])=O

InChI key

VBJGJHBYWREJQD-UHFFFAOYSA-M

agency

BP, ChP, JPE, Ph. Eur., USP

product line

EMPROVE® ESSENTIAL

form

solid

pH

4.5 (25 °C, 12 g/L in H2O)

mp

60 °C

solubility

850 g/L

density

1.915 g/cm3 at 20 °C

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-30°C

Quality Level

500

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Application

Sodium dihydrogen phosphate dihydrate is typically used as a phosphate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

1063450050: + 1063459011: + 1063459500: + 1063459029: + 1063459025: + CO1E1063451000: + 1063459026BWT: + 1063451000: + NACL1063450001: + 1063459999: + 1063459024: + 1063459336: + CO1E1063459026: + CO1E1063459025: + CO1E1063455000: + 1063450100: + 1063459013: + 1063459012: + 1063450000: + 1063451000BWT: + 1063455000: + 1063459026: + 1063455000BWT:

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Successfully Navigate the Regulatory Landscape for Chemicals and Single-Use Consumables

This page summarizes key considerations related to regulatory expectations for biomanufacturing including chemicals and polymeric materials. For chemicals, topics include nitrosamines and elemental impurities, and for polymeric materials such as filters and single-use assemblies, the focus is qualification and extractable and leachable testing.

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