1.08101

Tetrahydrofuran

for liquid chromatography LiChrosolv^®

• Synonym(s): THF, Tetramethylene oxide, Oxolane, Butylene oxide, Butylene oxide, Oxolane, Tetramethylene oxide
• Empirical Formula (Hill Notation): C₄H₈O
• CAS Number: 109-99-9
• Molecular Weight: 72.11
• Beilstein: 102391
• MDL number: MFCD00005356
• EC Index Number: 203-726-8

Properties

• vapor density: 2.5 (vs air)
• Quality Level: 100
• vapor pressure: 114 mmHg ( 15 °C); 143 mmHg ( 20 °C)
• product line: LiChrosolv^®
• grade: isocratic
• assay: ≥99.9% (GC)
• form: liquid
• autoignition temp.: 610 °F
• expl. lim.: 1.8-11.8 %
• technique(s): HPLC: suitable
• impurities: ≤0.0002 meq/g Acidity; ≤0.0002 meq/g Alkalinity; ≤0.02% Peroxide; ≤0.02% Water
• evapn. residue: ≤1.0 mg/L
• transmittance: 218 nm, ≥30%; 230 nm, ≥35%; 250 nm, ≥65%; 280 nm, ≥95%
• refractive index: n20/D 1.407 (lit.)
• pH: 7-8 (20 °C, 200 g/L in H₂O)
• bp: 65-67 °C (lit.)
• mp: −108 °C (lit.)
• transition temp: flash point -20 °C
• density: 0.889 g/mL at 25 °C (lit.)
• storage temp.: 2-30°C
• SMILES string: C1CCOC1
• InChI: 1S/C4H8O/c1-2-4-5-3-1/h1-4H2
• InChI key: WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

General description

LiChrosolv^® solvents have high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level. This makes them ideal for reproducible separations.

Application

Used as a solvent in chromatography applications.
Also featured in USP monograph methods for regulated pharmaceutical instrumental analysis.

Packaging

2.5 , 4 , 1, 10, 4, 5 l

Features and Benefits

• packaged in glass bottles
• offers high resolution, sensitivity and optimized peak baseline separation

Preparation Note

Product filtered through a 0.2 μm filter

Analysis Note

Purity (GC): ≥ 99.9 %
Identity (IR): conforms
Evaporation residue: ≤ 1.0 mg/l
Water: ≤ 0.02 %
Acidity: ≤ 0.0002 meq/g
Alkalinity: ≤ 0.0002 meq/g
Peroxide: ≤ 0.02 %
Transmission (at 218 nm): ≥ 30 %
Transmission (at 230 nm): ≥ 35 %
Transmission (at 250 nm): ≥ 65 %
Transmission (at 280 nm): ≥ 95 %
Filtred by 0.2µm filter

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H225 - H302 - H319 - H335 - H336 - H351
• Precautionary Statements: P202 - P210 - P233 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2
• Supplementary Hazards: EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): -6.2 °F - closed cup
• Flash Point(C): -21.2 °C - closed cup