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Safety Information

1.10110

SAFC

2-[4-(2-Hydroxyethyl)-1-piperazinyl]-ethanesulfonic acid

Buffer substance HEPES EMPROVE® EXPERT

Pharma Manufacturing

Synonym(s):

HEPES, 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid, N-(2-Hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid)

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About This Item

Empirical Formula (Hill Notation):
C8H18N2O4S
CAS Number:
Molecular Weight:
238.30
Beilstein:
883043
MDL number:
UNSPSC Code:
12161703
EC Index Number:
230-907-9

Quality Level

product line

EMPROVE® EXPERT

potency

>2000 mg/kg LD50, oral (Rat)

feature

RNase and DNase free

technique(s)

API processing | cocrystal formation: suitable

pH

5.0-5.5 (20 °C, 100 g/L in H2O)

useful pH range

6.8-8.2

pKa (25 °C)

7.5

mp

212.6 °C

solubility

703.6 g/L

density

1.44 g/cm3 at 20 °C

bulk density

560 kg/m3

storage temp.

2-25°C

SMILES string

OCCN1CCN(CC1)CCS(O)(=O)=O

InChI

1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)

InChI key

JKMHFZQWWAIEOD-UHFFFAOYSA-N

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General description

Our SAFC® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE® Program, our raw materials are offered with EMPROVE® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.
Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step.

Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

1101109999:
1101100250:
1101100003:
1101101000:
1101100025:
1101109025:
1101109028:
1101106010:
1.10110.1000A:
1101100000:
1101106025:
1.10110.1000DISC:


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