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175580

Sigma-Aldrich

Angiogenesis Inhibitor

The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonym(s):
Angiogenesis Inhibitor, ( Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one, (Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
Empirical Formula (Hill Notation):
C12H9N3O
CAS Number:
186611-44-9
Molecular Weight:
211.22

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

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This Item
324674654256-M178488
Angiogenesis Inhibitor The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

175580

Angiogenesis Inhibitor

EGFR Inhibitor The EGFR Inhibitor, also referenced under CAS 879127-07-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

324674

EGFR Inhibitor

TNF-α Inhibitor The TNF-α Inhibitor, also referenced under CAS 1049741-03-8, controls the biological activity of TNF-α.

Millipore

654256-M

TNF-α Inhibitor

Apoptosis Inhibitor The Apoptosis Inhibitor, also referenced under CAS 54135-60-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

178488

Apoptosis Inhibitor

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, desiccated

color

yellow

color

off-white

color

white

color

off-white

solubility

DMSO: 5 mg/mL

solubility

ethanol: 25 mg/mL, DMSO: 50 mg/mL

solubility

DMSO: 10 mg/mL

solubility

DMSO: 100 mg/mL, ethanol: 20 mg/mL

General description

A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
hEGF-R tyrosine kinase activity
Product competes with ATP.
Reversible: no
Target IC50: 54% inhibition at 10 µM against hEGF-R tyrosine kinase activity

Packaging

Packaged under inert gas

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Other Notes

Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem.18, 243.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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