Merck
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8.22184

Sigma-Aldrich

TWEEN® 20

for synthesis

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Synonym(s):
Montanox 20, Polysorbate 20, Polyethylene glycol sorbitan monolaurate, Polyoxyethylenesorbitan monolaurate
CAS Number:
MDL number:
EC Index Number:
500-018-3

vapor pressure

<1.4 hPa ( 20 °C)

Quality Level

form

liquid

potency

38900 mg/kg LD50, oral (Rat)

mol wt

~1228

refractive index

n20/D 1.468 (lit.)

pH

6-8 (20 °C, 50 g/L in H2O)

transition temp

flash point 275 °C

density

1.095 g/mL at 25 °C (lit.)

storage temp.

2-30°C

SMILES string

CCCCCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO

InChI

1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3

InChI key

HMFKFHLTUCJZJO-UHFFFAOYSA-N

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1 of 4

This Item
P8341P6585P7949
vibrant-m

8.22184

TWEEN® 20

-
vibrant-m

P8341

TWEEN® 20

-
vibrant-m

P6585

TWEEN® 20

-
vibrant-m

P7949

TWEEN® 20

Premium Grade
mol wt

~1228

mol wt

~1228

mol wt

~1228

mol wt

~1228

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

storage temp.

2-30°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

transition temp

flash point 275 °C

transition temp

cloud point 76 °C

transition temp

cloud point 76 °C

transition temp

cloud point 76 °C

density

1.095 g/mL at 25 °C (lit.)

density

1.095 g/mL at 25 °C (lit.), 1.1 g/cm3 at 25 °C (lit.)

density

1.095 g/mL at 25 °C (lit.), 1.1 g/cm3 at 25 °C (lit.)

density

1.095 g/mL at 25 °C (lit.)

General description

Tween®-20 is a polysorbate-based non-ionic surfactant. It is made up of three chemical units:
  • aliphatic ester chains that hinder biomolecules from nonspecific interactions
  • aliphatic chain that can be non-covalently adsorbed on a hydrophobic surface
  • hydrophilic terminal hydroxyl groups, which can be chemically modified for potential applications.

Application

Tween®-20 can be used as a structure-directing agent in the preparation of mesoporous oxide films because of its ability to promote textural properties of the films such as controllable crystallinity, film morphology, tailor-designed pore structure, high BET surface area, and controlled film thickness. It is also used in the synthesis of AuNPs/TWEEN/GO composites, where Tween®-20 acts as a reducing and immobilizing agent for AuNPs (Au nanoparticles) as well as a stabilizing agent for GO (graphene oxide).
Tween®-20 can also be used as an emulsifying, solubilizing, and wetting agent in a variety of liquid formulations.
Non-ionic detergent

Analysis Note

Density (d 20 °C/ 4 °C): 1.095 - 1.105
Hydroxyl value: 96 - 108
Saponification value: 40 - 50
Identity (IR): passes test
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

527.0 °F - Pensky-Martens closed cup

Flash Point(C)

275 °C - Pensky-Martens closed cup


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Designated Flammable Substances
Flammable liquid


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Chen Y, et al.
Chemical Engineering Journal, 170(2-3), 518-524 (2011)
Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines
Lo Yu-li
Journal of Controlled Release : Official Journal of the Controlled Release Society, 90(1), 37-48 (2003)
Development and evaluation of solid self nano-emulsifying formulation of rosuvastatin calcium for improved bioavailability
Kulkarni NS, et al.
Tropical Journal of Pharmaceutical Research, 14(4), 575-582 (2015)
Mass transport phenomena in oil-in-water emulsions containing surfactant micelles: Ostwald ripening
Weiss J, et al.
Langmuir, 16(17), 6833-6838 (2000)
Hierarchical macro-mesoporous structures in the system TiO2-Al2O3, obtained by hydrothermal synthesis using Tween-20 as a directing agent
Garcia-Benjume ML, et al.
Materials Characterization, 60(12), 1482-1488 (2009)

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