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8.51055

Sigma-Aldrich

DMAP

4-(Dimethylamino)pyridine Novabiochem®

Synonym(s):
DMAP, 4-Dimethylaminopyridine
Empirical Formula (Hill Notation):
C7H10N2
CAS Number:
Molecular Weight:
122.17
MDL number:
EC Index Number:
214-353-5

Quality Level

product line

Novabiochem®

Assay

≥99.0% (GC)

form

powder

autoignition temp.

420 °C

potency

140 mg/kg LD50, oral (Rat)
90 mg/kg LD50, skin (Rabbit)

reaction suitability

reaction type: Coupling Reactions

manufacturer/tradename

Novabiochem®

pH

11 (20 °C, 60 g/L in H2O)

bp

138-140 °C/24 hPa

mp

110-112 °C

transition temp

flash point 124 °C

bulk density

520 kg/m3

application(s)

peptide synthesis

storage temp.

2-30°C

InChI

1S/C7H10N2/c1-9(2)7-3-5-8-6-4-7/h3-6H,1-2H3/p+1

InChI key

VHYFNPMBLIVWCW-UHFFFAOYSA-O

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This Item
394051077008.51054
DMAP 4-(Dimethylamino)pyridine Novabiochem®

Sigma-Aldrich

8.51055

DMAP

CDI 1,1′-Carbonyldiimidazole Novabiochem®

Sigma-Aldrich

8.51054

CDI

form

powder

form

crystals, pellets

form

chips, crystalline powder, flakes

form

powder

pH

11 (20 °C, 60 g/L in H2O)

pH

-

pH

-

pH

7.7 (20 °C, 50 g/L in H2O)

bp

138-140 °C/24 hPa

bp

-

bp

-

bp

-

mp

110-112 °C

mp

108-110 °C (lit.), 111-114 °C

mp

108-110 °C (lit.)

mp

116-120 °C

storage temp.

2-30°C

storage temp.

-

storage temp.

room temp

storage temp.

2-8°C

General description

Catalyst for esterification and amidation reagents [1,2,3].

Literature references

[1] S. S. Wang, et al. (1981) Int. J. Peptide Protein Res., 18, 459.
[2] J.-P. Gamet, et al. (1984) Tetrahedron, 40, 1995.
[3] K. Takeda, et al. (1991) Synthesis, 1991, 689.

Linkage

Replaces: 01-62-0004

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (GC, area%): ≥ 99.0 % (a/a)
Melting range (lower value): ≥ 110 °C
Melting range (upper value): ≤ 113 °C

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 1

Target Organs

Nervous system

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

255.2 °F

Flash Point(C)

124 °C


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