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04573

Sigma-Aldrich

Thiamine hydrochloride

tested according to Ph. Eur.

Synonym(s):
Thiamio hydrochloridum, Aneurine hydrochloride, Vitamin B1 hydrochloride
Empirical Formula (Hill Notation):
C12H17ClN4OS · HCl
CAS Number:
Molecular Weight:
337.27
Beilstein:
3851771
EC Number:
MDL number:
eCl@ss:
34058006
PubChem Substance ID:
NACRES:
NA.26

biological source

synthetic

Quality Level

Agency

USP/NF
tested according to Ph. Eur.

Assay

98.5-101.0% anhydrous basis

form

solid

mp

250 °C (dec.) (lit.)

solubility

alcohol: soluble 1 gm in 100 ml (95%)
alcohol: soluble 1 gm in 315 ml (Absolute)
glycerol: soluble 1 gm in 18 ml
water: soluble 1 g/mL
benzene: insoluble
chloroform: insoluble
diethyl ether: insoluble
hexane: insoluble
methanol: very soluble
propylene glycol: soluble

storage temp.

2-8°C

SMILES string

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

InChI key

DPJRMOMPQZCRJU-UHFFFAOYSA-M

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1 of 4

This Item
PHR1037T45621656002
Thiamine hydrochloride tested according to Ph. Eur.

Sigma-Aldrich

04573

Thiamine hydrochloride

Thiamine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1037

Thiamine hydrochloride

Thiamine hydrochloride meets USP testing specifications

Sigma-Aldrich

T4562

Thiamine hydrochloride

Thiamine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1656002

Thiamine hydrochloride

assay

98.5-101.0% anhydrous basis

assay

-

assay

98.0-102.0%

assay

-

form

solid

form

solid

form

solid

form

-

mp

250 °C (dec.) (lit.)

mp

250 °C (dec.) (lit.)

mp

250 °C (dec.) (lit.)

mp

250 °C (dec.) (lit.)

solubility

alcohol: soluble 1 gm in 100 ml (95%), alcohol: soluble 1 gm in 315 ml (Absolute), glycerol: soluble 1 gm in 18 ml, water: soluble 1 g/mL, benzene: insoluble, chloroform: insoluble, diethyl ether: insoluble, hexane: insoluble, methanol: very soluble, propylene glycol: soluble

solubility

-

solubility

-

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

Application

Thiamine hydrochloride has been used as a keratin salts medium supplement for culturing log-phase fungus. It has also been used as a supplement of VB medium the minimal medium of Vogel and Bonner.

Biochem/physiol Actions

Thiamine hydrochloride is a cheap, non-toxic and efficient catalyst for the synthesis of amidoalkyl naphthols. It inhibits the production of shikonin derivatives by suspension cultures of Lithospermum erythrorhizon. Additionally, thiamine hydrochloride addition to apple juice concentrates reduces its patulin content.
Thiamine hydrochloride is a hydrochloride salt form of thiamine (Vitamin B1). It is crucial for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Thiamine hydrochloride as an efficient catalyst for the synthesis of amidoalkyl naphthols.
Min Lei
Tetrahedron Letters, 50, 6393-6397 (2009)
Y Fujita et al.
Plant cell reports, 1(2), 61-63 (1981-12-01)
An excellent new medium was developed for the production of shikonin derivatives by suspension cultures of Lithospermum erythrorhizon. We investigated the effects of all the components of White's medium on the production of these derivatives. Nitrate, phosphate, copper, sulfate and
G E Degnen et al.
Journal of bacteriology, 117(2), 477-487 (1974-02-01)
A mutator gene, mutD5, whose phenotype is conditional, has been identified in Escherichia coli. By P1 transduction it has been shown to lie at about 5.7 min on the chromosome, being co-transduced with proA and argF. In rich medium, streptomycin-
Thermodynamics of (solute+ solute) and (solute+ solvent) interactions of homologous series of amino acids with thiamine hydrochloride in aqueous medium at T=(305.15, 310.15, 315.15) K: A volumetric and acoustic approach
Kumar H and Behal I
The Journal of Chemical Thermodynamics, 102, 48-62 (2016)
G Apodaca et al.
Infection and immunity, 57(10), 3081-3090 (1989-10-01)
Trichophyton rubrum is the most common dermatophyte of humans and normally colonizes the superficial layers of the epidermis (stratum corneum). Several proteinases with a possible role in the metabolism of host proteins have been purified from this fungus. The regulation

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