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I0460000

Isoleucine

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

L-Isoleucine, (2S,3S)-2-Amino-3-methylpentanoic acid

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About This Item

Linear Formula:
C2H5CH(CH3)CH(NH2)CO2H
CAS Number:
73-32-5
Molecular Weight:
131.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329815310
MDL number:
MFCD00064222
Beilstein/REAXYS Number:
1721792

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InChI

1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1

SMILES string

CC[C@H](C)[C@H](N)C(O)=O

InChI key

AGPKZVBTJJNPAG-WHFBIAKZSA-N

grade

pharmaceutical primary standard

API family

leucine

manufacturer/tradename

EDQM

mp

288 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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1 of 4

This Item
1349502PHR1099I5281
Isoleucine European Pharmacopoeia (EP) Reference Standard

I0460000

Isoleucine

L-Isoleucine United States Pharmacopeia (USP) Reference Standard

USP

1349502

L-Isoleucine

L-Isoleucine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1099

L-Isoleucine

L-Isoleucine

SAFC

I5281

L-Isoleucine

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

-

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

-

API family

leucine

API family

leucine

API family

leucine

API family

-

mp

288 °C (dec.) (lit.)

mp

288 °C (dec.) (lit.)

mp

288 °C (dec.) (lit.)

mp

288 °C (dec.) (lit.)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Isoleucine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

I0460000: + I0460000-1EA:

jan

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Vijay Joshi et al.
Amino acids, 39(4), 933-947 (2010-02-27)
Pathways regulating threonine, methionine and isoleucine metabolism are very efficiently interconnected in plants. As both threonine and methionine serve as substrates for isoleucine synthesis, their synthesis and catabolism under different developmental and environmental conditions also influence isoleucine availability. Together, methionine
Jirí Svoboda et al.
Phytochemistry, 71(13), 1445-1449 (2010-06-24)
Our understanding of plant defensive mechanisms against herbivore and pathogen attack has significantly increased over the past decade. The complex cascade of defensive events is initiated and controlled by a network of interacting plant hormones. Especially, the conjugate of jasmonate
Anna L Vestergaard et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(14), E1334-E1343 (2014-04-08)
P4-ATPases (flippases) translocate specific phospholipids such as phosphatidylserine from the exoplasmic leaflet of the cell membrane to the cytosolic leaflet, upholding an essential membrane asymmetry. The mechanism of flipping this giant substrate has remained an enigma. We have investigated the
Song-Yu Yang et al.
Molecular genetics and metabolism, 92(1-2), 36-42 (2007-07-10)
The HSD17B10 gene maps on chromosome Xp11.2, a region highly associated with X-linked mental retardation. This gene encodes HSD10, a mitochondrial multifunctional enzyme that plays a significant part in the metabolism of neuroactive steroids and the degradation of isoleucine. The
O Søvik
Journal of inherited metabolic disease, 16(1), 46-54 (1993-01-01)
A review is presented of 22 published cases of verified or probable mitochondrial 2-methylacetoacetyl-CoA thiolase deficiency, a disorder of isoleucine and ketone body metabolism. The clinical expression, characterized by ketoacidosis, vomiting and lethargy, is highly variable. Typical age of onset
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