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I0460000

Isoleucine

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
L-Isoleucine, (2S,3S)-2-Amino-3-methylpentanoic acid
Linear Formula:
C2H5CH(CH3)CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein:
1721792
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

leucine

manufacturer/tradename

EDQM

mp

288 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC[C@H](C)[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1

InChI key

AGPKZVBTJJNPAG-WHFBIAKZSA-N

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1 of 4

This Item
1349502PHR10991.05357
Isoleucine European Pharmacopoeia (EP) Reference Standard

I0460000

Isoleucine

L-Isoleucine United States Pharmacopeia (USP) Reference Standard

1349502

L-Isoleucine

L-Isoleucine Pharmaceutical Secondary Standard; Certified Reference Material

PHR1099

L-Isoleucine

SAFC

1.05357

L-Isoleucine

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

format

neat

format

neat

format

neat

format

-

API family

leucine

API family

leucine

API family

leucine

API family

-

mp

288 °C (dec.) (lit.)

mp

288 °C (dec.) (lit.)

mp

288 °C (dec.) (lit.)

mp

279-280 °C (decomposition)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Isoleucine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Sigma-Aldrich

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L-Isoleucine from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Sigma-Aldrich

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DL-allo-Isoleucine ≥99.0%

Sigma-Aldrich

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DL-allo-Isoleucine

Millipore

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1.05362

L-Isoleucine

L-Leucine from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Sigma-Aldrich

L8912

L-Leucine

Proline European Pharmacopoeia (EP) Reference Standard

P3350000

Proline

L-Leucine reagent grade, ≥98% (HPLC)

Sigma-Aldrich

L8000

L-Leucine

Vijay Joshi et al.
Amino acids, 39(4), 933-947 (2010-02-27)
Pathways regulating threonine, methionine and isoleucine metabolism are very efficiently interconnected in plants. As both threonine and methionine serve as substrates for isoleucine synthesis, their synthesis and catabolism under different developmental and environmental conditions also influence isoleucine availability. Together, methionine
Anna L Vestergaard et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(14), E1334-E1343 (2014-04-08)
P4-ATPases (flippases) translocate specific phospholipids such as phosphatidylserine from the exoplasmic leaflet of the cell membrane to the cytosolic leaflet, upholding an essential membrane asymmetry. The mechanism of flipping this giant substrate has remained an enigma. We have investigated the
Jirí Svoboda et al.
Phytochemistry, 71(13), 1445-1449 (2010-06-24)
Our understanding of plant defensive mechanisms against herbivore and pathogen attack has significantly increased over the past decade. The complex cascade of defensive events is initiated and controlled by a network of interacting plant hormones. Especially, the conjugate of jasmonate
Song-Yu Yang et al.
Molecular genetics and metabolism, 92(1-2), 36-42 (2007-07-10)
The HSD17B10 gene maps on chromosome Xp11.2, a region highly associated with X-linked mental retardation. This gene encodes HSD10, a mitochondrial multifunctional enzyme that plays a significant part in the metabolism of neuroactive steroids and the degradation of isoleucine. The
Stanley H Korman
Molecular genetics and metabolism, 89(4), 289-299 (2006-09-05)
Three inborn errors have been identified in the pathway of isoleucine degradation. Deficiency of beta-ketothiolase (beta-KT, also known as T2, mitochondrial acetoacetyl-CoA thiolase and acetyl-CoA acetyltransferase 1) is a well-described disorder which presents with acute episodic ketoacidosis. In contrast, short/branched-chain

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