All Photos(1)



Alpha Tocopherol

Pharmaceutical Secondary Standard; Certified Reference Material

(±)-α-Tocopherol, Vitamin E, DL-all-rac-α-Tocopherol
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


certified reference material
pharmaceutical secondary standard




current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable


0.950 g/mL at 20 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)



pharmacopeia traceability

traceable to BP 882
traceable to PhEur T1550000
traceable to USP 1667600

SMILES string




InChI key


Looking for similar products? Visit Product Comparison Guide

General description

α-Tocopherol is a powerful biological antioxidant and the most active form of vitamin E in humans.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
α-Tocopherol may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using flow injection chemiluminescence technique.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAB3718 in the slot below. This is an example certificate only and may not be the lot that you receive.


Exclamation mark




Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK Germany


Flash Point F

235.4 °F - closed cup

Flash Point C

113 °C - closed cup

Certificate of Analysis

Certificate of Origin

Flow-injection determination of retinol and tocopherol in pharmaceuticals with acidic potassium permanganate chemiluminescence
Waseem A, et al.
Analytical Sciences, 25(3), 407-412 (2009)
Simultaneous determination of retinol and alpha-tocopherol in serum or plasma by liquid chromatography
Catignani LG and Bieri GJ
Clinical Chemistry, 29, 708-712 (1983)
Kirsten G Coupland et al.
Movement disorders : official journal of the Movement Disorder Society, 29(13), 1606-1614 (2014-01-01)
Parkinson's disease (PD) is a neurodegenerative disorder for which environmental factors influence disease risk and may act via an epigenetic mechanism. The microtubule-associated protein tau (MAPT) is a susceptibility gene for idiopathic PD. Methylation levels were determined by pyrosequencing of...
Seung-Ju Yang et al.
European journal of pharmacology, 736, 26-34 (2014-05-07)
Thiazole derivatives are attractive candidates for drug development because they can be efficiently synthesized and are active against a number of diseases and conditions, including diabetes. In our present study, we investigated the anti-inflammatory and antioxidant properties of N-adamantyl-4-methylthiazol-2-amine (KHG26693)...
Sam B Weber et al.
Proceedings. Biological sciences, 279(1731), 1077-1084 (2011-09-23)
The effect of climate warming on the reproductive success of ectothermic animals is currently a subject of major conservation concern. However, for many threatened species, we still know surprisingly little about the extent of naturally occurring adaptive variation in heat-tolerance....


HPLC Analysis of Fat Soluble Vitamins by Normal Phase Chromatography on Ascentis® Si

Separation of (±)-α-Tocopherol, analytical standard; Menadione (K3), analytical standard; (+)-γ-Tocopherol, analytical standard; Cholecalciferol (D3), analytical standard

HPLC Analysis of Vitamins, Fat Soluble (A and E), on SUPELCOSIL™ LC-18

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.

HPLC Analysis of Fat-Soluble Vitamins on Ascentis® Express C18, Methanol Mobile Phase

Separation of Retinyl acetate, analytical standard; δ-Tocopherol, analytical standard; Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard; (±)-α-Tocopherol, analytical standard; Vitamin E acetate, analytical standard; Phylloquinone (K1), analytical standard; Retinol palmitate, analytical standard.

HPLC Analysis of Fat Soluble Vitamins on Ascentis® Express RP-Amide, Acetonitrile Mobile Phase

Separation of Retinyl acetate, analytical standard; Vitamin E acetate, analytical standard; Phylloquinone (K1), analytical standard; Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard; (±)-α-Tocopherol, analytical standard; δ-Tocopherol, analytical standard; Retinol palmitate, analytical standard

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service