If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
PHR1148
4-Aminophenol (Acetaminophen Related Compound K) (Paracetamol Impurity K)
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
4-Aminophenol, 4-Hydroxyaniline
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
1 g | Check Cart for Availability | ¥13,900 |
About This Item
Quality Segment
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0001955, traceable to USP 1021204
API family
mesalazine, paracetamol, acetaminophen
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
185-189 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
Nc1ccc(O)cc1
InChI
1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2
InChI key
PLIKAWJENQZMHA-UHFFFAOYSA-N
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is a primary degradation product of the widely used antipyretic and analgesic drug acetaminophen, also known as paracetamol, formed on its hydrolysis.[1]
Application
- Separation and estimation of acetaminophen and its process impurities in commercial acetaminophen tablets using high-performance liquid chromatography (HPLC)[1]
- Simultaneous electrochemical determination of acetaminophen and its impurity K using a reduced graphene oxide-titanium nitride (RGO-TiN) nanohybrid
- Development and validation of HPLC-based stability indicating method for the determination of acetaminophen, chlorpheniramine maleate, and their possible degradation products in an over-the-counter syrup formulation
- Determination of acetaminophen, pamabrom, and their impurities using high-performance thin layer chromatography (HPTLC) and reversed phase-high performance liquid chromatography (RP-HPLC), according to the ICH guidelines, in their combined dosage tablets[2]
- Combined analysis of acetaminophen, chlorzoxazone, and their major degradation impurities using thin-layer chromatographic (TLC)-densitometric method in their combined dosage capsules[3]
Analysis Note
Other Notes
1 of 1
This Item | |||
|---|---|---|---|
| application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) agriculture |
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - | technique(s) HPLC: suitable, gas chromatography (GC): suitable |
| format neat | format neat | format neat | format neat |
| Quality Level 300 | Quality Level - | Quality Level - | Quality Level 100 |
| grade certified reference material, pharmaceutical secondary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard | grade analytical standard |
| storage temp. 2-30°C | storage temp. - | storage temp. 2-8°C | storage temp. - |
signalword
Warning
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Skin Sens. 1 - STOT RE 2
target_organs
Kidney
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
Class I Designated Chemical Substances
prtr
Substances Subject to be Indicated Names
ishl_indicated
Substances Subject to be Notified Names
ishl_notified
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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