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Merck

Y0000438

Coumarin

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1,2-Benzopyrone, 1-Benzopyran-2-one, 2H-Chromen-2-one

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160 MG

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About This Item

Empirical Formula (Hill Notation):
C9H6O2
CAS Number:
Molecular Weight:
146.14
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
383644

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InChI

1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H

SMILES string

O=C1Oc2ccccc2C=C1

InChI key

ZYGHJZDHTFUPRJ-UHFFFAOYSA-N

grade

pharmaceutical primary standard

vapor pressure

0.01 mmHg ( 47 °C)

API family

coumarin

manufacturer/tradename

EDQM

bp

298 °C (lit.)

mp

68-73 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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1 of 4

This Item
0126059572609PHL80017
manufacturer/tradename

EDQM

manufacturer/tradename

HWI

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

manufacturer/tradename

PhytoLab

grade

pharmaceutical primary standard

grade

primary reference standard

grade

certified reference material, TraceCERT®

grade

primary reference standard

format

neat

format

-

format

neat

format

-

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
environmental
flavors and fragrances
food and beverages
personal care

application(s)

-

vapor pressure

0.01 mmHg ( 47 °C)

vapor pressure

0.01 mmHg ( 47 °C)

vapor pressure

0.01 mmHg ( 47 °C)

vapor pressure

0.01 mmHg ( 47 °C)

API family

coumarin

API family

-

API family

-

API family

-

Application

Coumarin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

323.6 °F - closed cup

flash_point_c

162 °C - closed cup


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

Y0000438-1EA: + Y0000438: + Y0000438-80MG:

jan


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Donglei Yu et al.
Medicinal research reviews, 23(3), 322-345 (2003-03-21)
Numerous plant-derived compounds have been evaluated for inhibitory effects against HIV replication, and some coumarins have been found to inhibit different stages in the HIV replication cycle. This review article describes recent progress in the discovery, structure modification, and structure-activity
Musiliyu A Musa et al.
Current medicinal chemistry, 15(26), 2664-2679 (2008-11-11)
The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in natural products (such as the anticoagulant warfarin) that display interesting pharmacological properties, has intrigued chemists and medicinal chemists for decades to explore the natural coumarins or synthetic analogs for their applicability
B G Lake
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(4), 423-453 (1999-07-27)
The metabolism, toxicity and results of tests for carcinogenicity have been reviewed with respect to the safety for humans of coumarin present in foodstuffs and from fragrance use in cosmetic products. Coumarin is a natural product which exhibits marked species
E Danese et al.
Clinical pharmacology and therapeutics, 92(6), 746-756 (2012-11-08)
A systematic review and a meta-analysis were performed to quantify the accumulated information from genetic association studies investigating the impact of the CYP4F2 rs2108622 (p.V433M) polymorphism on coumarin dose requirement. An additional aim was to explore the contribution of the
A Marjolein Schrijver et al.
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 22(1), 87-95 (2015-03-17)
To report the results of the Dutch randomized trial comparing standard catheter-directed and ultrasound-accelerated thrombolysis (UST) for the treatment of arterial thromboembolic occlusions. The DUET study ( controlled-trials.com ; identifier ISRCTN72676102) was designed to assess whether UST can reduce therapy

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