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34851

Sigma-Aldrich

Acetonitrile

≥99.9%, gradient grade, suitable for HPLC

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Synonym(s):
ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide
Linear Formula:
CH3CN
CAS Number:
Molecular Weight:
41.05
Beilstein:
741857
EC Number:
MDL number:
UNSPSC Code:
41116105
eCl@ss:
39031501
PubChem Substance ID:
NACRES:
NA.03

grade

gradient grade

Quality Level

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

Assay

≥99.9%

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

baseline drift measuring range

≤15 mAU (210 nm)

technique(s)

HPLC: suitable

impurities

≤0.0002% free alkali (as NH3)
≤0.0005% non-volatile matter
≤0.001% free acid (as CH3COOH)
≤0.02% water (Karl Fischer)
≤0.5 ppb fluorescence (quinine) at 365 nm
≤1 ppb fluorescence (quinine) at 254 nm

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

density

0.786 g/mL at 25 °C (lit.)

HPLC-gradient

≤0.5 mAU at 254 nm
≤3 mAU at 210 nm

UV absorption

λ: 195 nm Amax: ≤0.12
λ: 200 nm Amax: ≤0.032
λ: 230 nm Amax: ≤0.0044
λ: 235 nm Amax: ≤0.0044
λ: 250 nm Amax: ≤0.0044
λ: 400 nm Amax: ≤0.0044

application(s)

food and beverages

format

neat

storage temp.

room temp

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

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General description

Acetonitrile (MeCN) is widely employed as a solvent in various studies and has high dielectric constant (37.5). Various purification procedures to obtain different grades of acetonitrile for use in different studies (polarography, spectroscopy, etc.) have been reported by many researchers.

Application

Acetonitrile (MeCN) may be used as an extraction solvent during the quantification of pesticide residues in fruits and vegetables.

Preparation Note

Product filtered through a 0.2 μm filter

Other Notes

Important notice
  • The article number 34851-4X2.5L will be discontinued. Please order the single bottle 34851-2.5L which is physically identical with the same exact specifications.
  • The article number 34851-6X1L will be discontinued. Please order the single bottle 34851-1L which is physically identical with the same exact specifications.

Recommended products

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

Pure-Pac is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

WGK

WGK 2

Flash Point(F)

35.6 °F

Flash Point(C)

2.0 °C


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

34851E-2.5L:
34851-10L-RC:
34851P-4X2.5L:4548173259475
34851-20L-P2:4548173259383
34851S-5L:
34851-20L:
34851-4L:4548173218359
34851-1L:4548173218335
34851S-395L:4548173259499
34851S-50L:
34851S-20L:
34851-18L:4548173259369
34851S-5BAR-200L:
34851-4X3L:
34851-200LP2-4B-LS:
34851-H:
34851-200L-P2:
34851-200L-LS-NB:
34851-4X2L:4548173259413
34851-200L-P1SBBK:
34851-3L:4548173228341
34851S-45L:4548173259505
34851-30L:
34851-50L-P2-4B:
34851-72X2.5L:4548173259451
34851-200L-P2-SA:
34851-215L-C01:
34851-18L-P1:
34851-200L-LS:
34851P-2.5L:
34851-200L-LSNBBK:
34851-200L-P1-LS:
34851-50L-P2-LS:
34851-144X1L:4548173259352
34851-100ML:4548173218410
34851-EW-200L-P1SB:
34851-6X1L:4548173259444
34851-108X2.5L:
34851-4X4L:4548173259420
34851S-18L:
34851-200L-P1-SB:
34851-2.5L-PC:
34851E-4X2.5L:
34851-20L-N1:
34851S-30L-RC:
34851-2.5L:4548173228327
34851-200L-P2-B:
34851-2L:4548173218342
34851D-2.5L:
34851-4X2.5L:4548173311685
34851-BULK:
34851-VS-50L-P1:
34851-200L:4548173259376
34851-50L-P2-4B-LS:
34851N-72X2.5L:
34851-HU-20L-P2:
34851-7L:4548173259468
34851S-1385L-R:
34851-45L:4548173259390
34851-VAR:
34851S-400L-RC:
34851S-1000L:
34851-CR-200L-P2:
34851-PZ:4548173259482
34851-50L-P2:
34851-56L:4548173259437
34851-56L-P1-LS:
34851-200L-P2-LS:


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Purification of acetonitrile.
Walter M and Ramaley L.
Analytical Chemistry, 45(1), 165-166 (1973)
Michelangelo Anastassiades et al.
Journal of AOAC International, 86(2), 412-431 (2003-05-02)
A simple, fast, and inexpensive method for the determination of pesticide residues in fruits and vegetables is introduced. The procedure involves initial single-phase extraction of 10 g sample with 10 mL acetonitrile, followed by liquid-liquid partitioning formed by addition of
Timo Glatter et al.
Molecular systems biology, 5, 237-237 (2009-01-22)
Protein complexes represent major functional units for the execution of biological processes. Systematic affinity purification coupled with mass spectrometry (AP-MS) yielded a wealth of information on the compendium of protein complexes expressed in Saccharomyces cerevisiae. However, global AP-MS analysis of
Hélène Hall et al.
Brain : a journal of neurology, 137(Pt 9), 2493-2508 (2014-07-27)
The neuropathological substrate of dementia in patients with Parkinson's disease is still under debate, particularly in patients with insufficient alternate neuropathology for other degenerative dementias. In patients with pure Lewy body Parkinson's disease, previous post-mortem studies have shown that dopaminergic
Divya Subramonian et al.
Journal of proteome research, 13(9), 3905-3918 (2014-07-30)
SUMOylation is an essential posttranslational modification and regulates many cellular processes. Dysregulation of SUMOylation plays a critical role in metastasis, yet how its perturbation affects this lethal process of cancer is not well understood. We found that SUMO-2/3 modification is

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