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Safety Information

86339

Sigma-Aldrich

Sodium taurocholate hydrate

≥97.0% (TLC)

Synonym(s):

Taurocholic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C26H44NNaO7S · xH2O
CAS Number:
Molecular Weight:
537.68 (anhydrous basis)
Beilstein:
3901620
EC Number:
MDL number:
UNSPSC Code:
12161902
PubChem Substance ID:
NACRES:
NA.77

biological source

ox bile
synthetic

description

anionic

Assay

≥97.0% (TLC)

form

powder

optical activity

[α]20/D +23±1°, c = 3% in H2O (dry matter)

mol wt

537.68 g/mol (anhydrous basis)

impurities

≤1% taurine
≤2% cholic acid

solubility

H2O: 50 mg/mL, clear

functional group

sulfonic acid

SMILES string

O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C26H45NO7S.Na.H2O/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);;1H2/q;+1;/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;;/m1../s1

InChI key

RDAJAQDLEFHVNR-NEMAEHQESA-M

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Application

Sodium taurocholate hydrate was used as an emulsifier in in situ preparation of digestive enzymes.

Biochem/physiol Actions

Taurocholic acid is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and deoxycholic acid. These are reabsorbed by the liver via a carrier-mediated process and converted by liver enzymes to taurocholic acid.

Preparation Note

Sodium taurocholate hydrate yields a clear, colorless solution in water at 50 mg/ml.

Other Notes

For the solubilization of unconjugated bilirubin

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

86339-BULK:
86339-VAR:
86339-25G:
86339-5G:
86339-1G:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Extreme tolerance to environmental stress of sexual and parthenogenetic resting eggs of Eucypris virens (Crustacea, Ostracoda)
Vandekerkhove J et al
Freshwater Biology, 58, 237-247 (2013)
Effect of biliary drainage on individual reactions in the conversion of cholesterol to taurochlic acid. Bile acids and steroids 180.
H Danielsson et al.
European journal of biochemistry, 2(1), 44-49 (1967-07-01)
L R Schwarz et al.
European journal of biochemistry, 55(3), 617-623 (1975-07-15)
Binding and transport characteristics for uptake of taurocholic acid by isolated rat liver cells were studied. 1. An adsorption of taurocholate to the cell surface is terminated in less than 15 s. A Ks of 0.55 mM and a total
Andrea Martinez Aguirre et al.
PLoS pathogens, 17(10), e1010015-e1010015 (2021-10-20)
Clostridioides difficile infections occur upon ecological / metabolic disruptions to the normal colonic microbiota, commonly due to broad-spectrum antibiotic use. Metabolism of bile acids through a 7α-dehydroxylation pathway found in select members of the healthy microbiota is regarded to be
Caiming Xu et al.
Journal of cellular and molecular medicine, 25(4), 1851-1866 (2021-01-14)
Long non-coding RNAs (lncRNAs) contribute to disease pathogenesis and drug treatment effects. Both emodin and dexamethasone (DEX) have been used for treating severe acute pancreatitis-associated acute lung injury (SAP-ALI). However, lncRNA regulation networks related to SAP-ALI pathogenesis and drug treatment

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