A1887

Albumin from human serum

lyophilized powder, essentially fatty acid free

• Synonym(s): HSA
• CAS Number: 70024-90-7
• EC Number: 274-272-6
• MDL number: MFCD00081418
• eCl@ss: 42010201

Properties

• biological source: human
• Quality Level: 300
• Assay: ≥96% (agarose gel electrophoresis)
• form: lyophilized powder
• mol wt: monomer calculated mol wt 66478 Da
• technique(s): ELISA: suitable; tissue culture: suitable; western blot: suitable
• impurities: HIV I and HIVII, HCV and HBsAg, tested negative; ≤0.007% Fatty Acids
• solubility: H₂O: soluble 50 mg/mL, clear to slightly hazy
• UniProt accession no.: P02768
• storage temp.: 2-8°C
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChI key: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• Gene Information: human ... ALB(213)

Description

General description

Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.

Application

Albumin from human serum has been used:

• as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteins
• to study the adsorption of water and acetonitrile (AN) vapor on a human serum albumin
• to study its effect on wound healing process

Biochem/physiol Actions

Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.

Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport. The albumin levels in the serum indicate the disease progression in advanced liver disease. Low body weight and decreased serum albumin is associated with colorectal cancer.

Preparation Note

Prepared from albumin (A1653)

Other Notes

View more information on human serum albumin.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves