Merck
All Photos(1)

A6060

Sigma-Aldrich

Calpain Inhibitor II

powder

Synonym(s):
N-Acetyl-L-leucyl-L-leucyl-L-methioninal
Empirical Formula (Hill Notation):
C19H35N3O4S
CAS Number:
Molecular Weight:
401.56
Beilstein:
7693643
MDL number:
PubChem Substance ID:
NACRES:
NA.77

assay

≥95% (HPLC)

Quality Level

form

powder

color

white

solubility

ethanol: 20 mg/mL

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

InChI

1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1

InChI key

RJWLAIMXRBDUMH-ULQDDVLXSA-N

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Application

Calpain Inhibitor II has been used in western blotting. It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle.
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

Other Notes

Formerly CAS# 136632-32-1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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