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Synonym(s):
CRISPR, CRISPRs, Cas9, Crispr RNA, Crispr/Cas System
Joshua R York et al.
Developmental biology, 453(2), 180-190 (2019-06-19)
A major challenge in vertebrate evolution is to identify the gene regulatory mechanisms that facilitated the origin of neural crest cells and placodes from ancestral precursors in invertebrates. Here, we show in lamprey, a primitively jawless vertebrate, that the transcription
Thomas Gaj et al.
Trends in biotechnology, 31(7), 397-405 (2013-05-15)
Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) comprise a powerful class of tools that are redefining the boundaries of biological research. These chimeric nucleases are composed of programmable, sequence-specific DNA-binding modules linked to a nonspecific DNA cleavage domain.
Hirotaka Ebina et al.
Scientific reports, 3, 2510-2510 (2013-08-27)
Even though highly active anti-retroviral therapy is able to keep HIV-1 replication under control, the virus can lie in a dormant state within the host genome, known as a latent reservoir, and poses a threat to re-emerge at any time.
Marian L Burr et al.
Cancer cell, 36(4), 385-401 (2019-10-01)
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates coordinated transcriptional silencing of the MHC-I antigen processing
Ari E Friedland et al.
Nature methods, 10(8), 741-743 (2013-07-03)
We report the use of clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease Cas9 to target genomic sequences in the Caenorhabditis elegans germ line using single-guide RNAs that are expressed from a U6 small nuclear RNA promoter. Our results demonstrate

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