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F5386

Sigma-Aldrich

Fibrin from human plasma

insoluble powder

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CAS Number:
9001-31-4
EC Number:
232-597-0
MDL number:
MFCD00131058
NACRES:
NA.61

biological source

human plasma

Quality Level

200

form

powder

technique(s)

indirect ELISA: suitable

UniProt accession no.

P02671
P02675
P02679

InChI

1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)

InChI key

BWGVNKXGVNDBDI-UHFFFAOYSA-N

Gene Information

human ... FGA(2243) , FGB(2244) , FGG(2266)

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This Item
F4883F8630F6755
Fibrin from human plasma insoluble powder

Sigma-Aldrich

F5386

Fibrin from human plasma

Fibrinogen from human plasma 35-65% protein (≥90% of protein is clottable).

Sigma-Aldrich

F4883

Fibrinogen from human plasma

Fibrinogen from bovine plasma Type I-S, 65-85% protein (≥75% of protein is clottable)

Sigma-Aldrich

F8630

Fibrinogen from bovine plasma

Fibrinogen from rat plasma 60-80% protein (≥60% of protein is clottable)

Sigma-Aldrich

F6755

Fibrinogen from rat plasma

form

powder

form

powder

form

powder

form

powder

technique(s)

indirect ELISA: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable, immunoblotting: suitable

UniProt accession no.

P02671, P02675, P02679

UniProt accession no.

P02671, P02675, P02679

UniProt accession no.

P02672, P02676, P12799

UniProt accession no.

P02680, P06399, P14480

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

Gene Information

cow ... FGA(522039), FGB(510522), FGG(280792)

Gene Information

rat ... Fga(361969), Fgb(24366), Fgg(24367)

General description

Fibrin is produced from cross-linking of fibrinogen by thrombin. Fibrinogen is made up of two monomers each containing three polypeptide chains. Fibrinogen is a major plasma protein.

Application

Fibrin from human plasma has been used:
  • for in vitro cleavage of fibrinogen and fibrin
  • as a reference for true component analysis (TCA) and principal component analysis (PCA) of Raman spectra
  • as a reference in Raman spectroscopy to study the binding mechanisms and the binding efficiency of the different polyoxometalates (POMs)

Biochem/physiol Actions

Fibrin acts as an important bio-polymer in the primary blood clotting process. It creates a scaffold for infiltrating cells during tissue repair. Fibrin is widely used as a tissue sealant for tissue regeneration applications as it enables the formation of a biocompatible physical structure. It is also used in delivery systems for cells and bioactive molecules. The fibrin matrix resembles the native pancreas and can serve as a scaffold material for islet transplantation. Fibrin has been used in studies to obtain fibrin-specific monoclonal antibodies (mAbs). These mAbs may be used to determine their role in fibrin polymerization and use in fibrin quantification in blood plasma.

Preparation Note

Prepared by clotting fibrinogen to yield a crosslinked fibrin

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Thrombin from human plasma lyophilized powder, ≥2,000 NIH units/mg protein (E1%/280, 18.3)

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The effect of etanercept on lung leukocyte margination and fibrin deposition after cardiac surgery.
Barry Dixon et al.
American journal of respiratory and critical care medicine, 188(6), 751-754 (2013-09-17)
Craig P Fischer et al.
Journal of the American College of Surgeons, 217(3), 385-393 (2013-08-24)
This study evaluated the hemostatic effectiveness and safety of Fibrin Pad (Omrix Biopharmaceuticals Ltd.) vs absorbable hemostat in patients undergoing nonemergent surgery. Fibrin Pad is a topical absorbable hemostat designed to be effective in a variety of soft tissues and
Kristen T Morin et al.
Experimental cell research, 319(16), 2409-2417 (2013-06-27)
In vitro models of endothelial assembly into microvessels are useful for the study of angiogenesis and vasculogenesis. In addition, such models may be used to provide the microvasculature required to sustain engineered tissues. A large range of in vitro models
Suk Ho Bhang et al.
Biomaterials, 34(30), 7247-7256 (2013-07-06)
While subcutaneous tissue has been proposed as a potential site for pancreatic islet transplantation, concern remains that the microvasculature of subcutaneous tissue is too poor to support transplanted islets. In an effort to overcome this limitation, we evaluated whether fibrin
Matteo Centola et al.
Tissue engineering. Part A, 19(17-18), 1960-1971 (2013-04-25)
Standard cartilage tissue engineering approaches, for example, matrix-induced autologous chondrocyte implantation (MACI), consist of the implantation of cell-based constructs whose survival and further development first depend on the degree of graft maturity at the time of surgery (e.g., matrix production)
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