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Safety Information

G6784

Sigma-Aldrich

ʟ-Glutamine–Penicillin–Streptomycin

solution, suitable for cell culture, BioReagent

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Synonym(s):
Pen/Strep, Penicillin/Streptomycin 
MDL number:
MFCD00283636
UNSPSC Code:
12352207
NACRES:
NA.76

product name

L-Glutamine–Penicillin–Streptomycin solution, L-glutamine 200 mM, streptomycin 10 mg/mL, penicillin 10,000 units, 0.1 μm filtered, BioReagent, suitable for cell culture

biological source

synthetic

Quality Level

300

description

stabilized

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

composition

L-glutamine, 200 mM
penicillin, 10,000 units
streptomycin, 10 mg/mL

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes
protein synthesis | interferes

storage temp.

−20°C

Related Categories

Application

This antibiotic solution is used to reduce or eliminate bacterial contamination in primary cell cultures. It is recommended for us at 10 mL/L.

Biochem/physiol Actions

Mode of Action: The product acts in three ways: Glutamine is an essential energy source for most mammalian cells in culture due to its amino acid carbon skeleton. Penicillin inhibits bacterial cell wall synthesis. Streptomycin inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding.

Antimicrobial spectrum: This product acts against both gram-negative and gram-positive bacteria.

Components

This solution is formulated to contain 200 mM L-glutamine, 10,000 units of Penicillin and 10 mg/mL of streptomycin, solubilized in a proprietary buffer.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

G6784-VAR:
G6784-10X5ML-PW:
G6784-100ML-PW:
G6784-10X5ML:
G6784-100ML:
G6784-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zhengliang L Wu et al.
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Lamin B Cham et al.
Cell reports, 31(2), 107494-107494 (2020-04-16)
Paradoxically, early host responses to infection include the upregulation of the antiphagocytic molecule, CD47. This suggests that CD47 blockade could enhance antigen presentation and subsequent immune responses. Indeed, mice treated with anti-CD47 monoclonal antibody following lymphocytic choriomeningitis virus infections show
Kate M Herum et al.
Journal of the American Heart Association, 9(3), e013518-e013518 (2020-02-01)
Background Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts. This initially provides essential mechanical support to the heart, but eventually
Miriam Gonzalez Gonzalez et al.
Journal of immunological methods, 457, 73-77 (2018-02-25)
Standard cell culturing on plastic plates (two dimensional (2D) cultures) does not represent the actual microenvironment where cells reside in tissues. The three dimensional (3D) systems, composed of extracellular matrix and/or pure amino acids which form a scaffold for cells
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