H7379

Hemoglobin human

lyophilized powder

• Synonym(s): Hb
• CAS Number: 9008-02-0
• MDL number: MFCD00131282
• eCl@ss: 42030116
• NACRES: NA.61

Properties

• biological source: human
• Quality Level: 200
• form: lyophilized powder
• technique(s): enzyme immunoassay: suitable
• impurities: HIV and hepatitis B antigen, tested negative
• solubility: H₂O: soluble 20 mg/mL
• UniProt accession no.: P02008; P02042; P02100; P09105; P68871; P69891; P69892; P69905
• storage temp.: 2-8°C
• Gene Information: human ... HBA1(3039) , HBA2(3040) , HBB(3043) , HBD(3045) , HBE1(3046) , HBG1(3047) , HBG2(3048) , HBQ1(3049) , HBZ(3050)

Description

General description

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.

Application

Hemoglobin was used in the development of a rapid enzyme immunoassay for the detection of retinol-binding protein. It was also used in the inhibition of human platelet reactivity by endothelium-derived relaxing factor.

Biochem/physiol Actions

The Fe²⁺/Fe³⁺ balance is a physiological indicator of blood oxygenation. Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.

Oxygen transporter, NO scavenger

Caution

Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable