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Safety Information

M5308

Sigma-Aldrich

L-Methionine

99.0-101.0%, suitable for cell culture, BioXtra, non-animal source

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Synonym(s):
(S)-2-Amino-4-(methylmercapto)butyric acid, L-2-Amino-4-(methylthio)butanoic acid
Linear Formula:
CH3SCH2CH2CH(NH2)CO2H
CAS Number:
63-68-3
Molecular Weight:
149.21
Beilstein:
1722294
EC Number:
200-562-9
MDL number:
MFCD00063097
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24896818
NACRES:
NA.26

biological source

non-animal source

Quality Level

300

Agency

USP/NF
meets EP testing specifications
meets JP testing specifications
meets USP testing specifications

product line

BioXtra

Assay

99.0-101.0%

form

powder

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

284 °C (dec.) (lit.)

solubility

H2O: 25 mg/mL

application(s)

peptide synthesis
pharmaceutical (small molecule)

SMILES string

CSCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI key

FFEARJCKVFRZRR-BYPYZUCNSA-N

Gene Information

rat ... Ggt1(116568)

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Application

L-Methionine has been used as a component of media to culture various cancer cells and to study its effects on the cell cycle. It has also been used as a component of DMEM medium to culture satellite cells from the white muscle of trouts.

Biochem/physiol Actions

Methionine is an essential amino acid which acts a precursor for transmethylation and transsulphuration. In proteins, L-methionine is the biologically active form. The adenosylation of methionine results in the formation of S-adenosyl-L-methionine (SAM), which serves as a methyl donor to various substances. L-Methionine′s metabolic product glutathione is known to regulate immune response and has antiviral action.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

M5308-100G:
M5308-25G:
M5308-BULK:
2513144:
M5308-VAR:
2540102:
M5308-25KG:
M5308-10MG:
M5308-1KG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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miR-210 expression is associated with methionine-induced
differentiation of trout satellite cells
Mary Latimer
The Journal of Experimental Biology (2017)
L-methionine as immune supportive supplement: a clinical evaluation.
Van Brummelen
Amino Acids, 33(1) (2007)
Suppression by L-Methionine of Cell Cycle Progression in LNCaP and MCF-7 Cells but not Benign Cells
Maximo A
Anticancer Research (2010)
Bio-Methionine Production from Glucose - Cost Analysis - Methionine E31A (2016)
Chien-Kuang Cornelia Ding et al.
Nature metabolism, 2(3), 270-277 (2020-05-29)
Critical to the bacterial stringent response is the rapid relocation of resources from proliferation toward stress survival through the respective accumulation and degradation of (p)ppGpp by RelA and SpoT homologues. While mammalian genomes encode MESH1, a homologue of the bacterial
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