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Merck

PHG0006

Guanidine hydrochloride

Synonym(s):

Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride

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About This Item

Linear Formula:
NH2C(=NH)NH2 · HCl
CAS Number:
50-01-1
Molecular Weight:
95.53
EC Number:
200-002-3
UNSPSC Code:
12352107
NACRES:
NA.21
Beilstein/REAXYS Number:
3591990
MDL number:
MFCD00013026

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InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

InChI key

PJJJBBJSCAKJQF-UHFFFAOYSA-N

SMILES string

Cl[H].NC(N)=N

biological source

synthetic

form

powder

impurities

Endotoxin, microbial, and trace metals; tested

pH

(25 °C, 4.6 - 6/573 g/L)

mp

180-185 °C (lit.)

solubility

H2O: 6 M at 20 °C, clear, colorless

density

1.3 g/cm3 (lit.)

suitability

suitable for manufacturing use

foreign activity

Dnase and RNase; tested

Quality Level

400

Gene Information

human ... KCNA1(3736), KCNA10(3744), KCNA2(3737), KCNA3(3738), KCNA4(3739), KCNA5(3741), KCNA6(3742), KCNA7(3743), KCNB1(3745), KCNB2(9312), KCNC1(3746), KCNC2(3747), KCNC3(3748), KCNC4(3749), KCND1(3750), KCND2(3751), KCND3(3752), KCNF1(3754), KCNG1(3755), KCNG2(26251), KCNG3(170850), KCNG4(93107), KCNH1(3756), KCNH2(3757), KCNH3(23416), KCNH4(23415), KCNH5(27133), KCNH6(81033), KCNH7(90134), KCNH8(131096), KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479), KCNS1(3787), KCNS2(3788), KCNS3(3790), KCNV1(27012), KCNV2(169522)

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1 of 4

This Item
5093350950G4505
Guanidine hydrochloride

SAFC

PHG0006

Guanidine hydrochloride

Guanidine hydrochloride BioUltra, Molecular Biology, ≥99.5% (AT)

Sigma-Aldrich

50933

Guanidine hydrochloride

Guanidine hydrochloride ≥98%

Sigma-Aldrich

50950

Guanidine hydrochloride

Guanidine hydrochloride organic base and chaeotropic agent, ≥99% (titration)

Sigma-Aldrich

G4505

Guanidine hydrochloride

biological source

synthetic

biological source

synthetic

biological source

-

biological source

synthetic (organic)

form

powder

form

powder or crystals

form

powder or crystals

form

crystalline powder

impurities

Endotoxin, microbial, and trace metals; tested

impurities

DNases, none detected, RNases, none detected, insoluble matter, passes filter test, phosphatases, none detected, proteases, none detected

impurities

-

impurities

≤0.3% water (Karl Fischer)

suitability

suitable for manufacturing use

suitability

-

suitability

-

suitability

-

foreign activity

Dnase and RNase; tested

foreign activity

-

foreign activity

-

foreign activity

-

pH

(25 °C, 4.6 - 6/573 g/L)

pH

4.5-6.0 (25 °C, 6 M in H2O)

pH

(25 °C, 4.6 - 6/573 g/L)

pH

(25 °C, 4.6 - 6 at 573 g/L)

Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

comparable product

Product No.
Description
Pricing

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000371357
0000371359
0000371361
0000371361
0000371359

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