Merck
  • SML1186
All Photos(1)

SML1186

Sigma-Aldrich

GGTI-286 dihydrochloride

≥90% (HPLC)

All Photos(1)
Synonym(s):
(R)-N-[[5-[(2-Amino-3-mercaptopropyl)amino][1,1′-biphenyl]-2-yl]carbonyl]-L-lLeucine methyl ester dihydrochloride, GGTI 286 dihydrochloride, N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1′-biphenyl]-2-yl]carbonyl]-L-leucine methyl ester dihydrochloride
Empirical Formula (Hill Notation):
C23H31N3O3S · 2HCl
CAS Number:
171744-11-9
Molecular Weight:
502.50
NACRES:
NA.77

Assay

≥90% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: 20 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

Compare Similar Items

View Full Comparison

1 of 4

This Item
G3545SML3185D052
Sigma-Aldrich

Sigma-Aldrich

SML1186

GGTI-286 dihydrochloride

GW583340 dihydrochloride ≥97% (HPLC), solid

Sigma-Aldrich

G3545

GW583340 dihydrochloride

CGP 48664 dihydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML3185

CGP 48664 dihydrochloride

GBR 12909 dihydrochloride solid, ≥98% (HPLC)

Sigma-Aldrich

D052

GBR 12909 dihydrochloride

assay

≥90% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

solid

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

-

color

white to light brown

color

-

color

white to beige

color

white

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 9 mg/mL

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: >5 mg/mL (Solutions freshly prepared daily)

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

Biochem/physiol Actions

GGTI-286 is a cell permeable, potent and selective inhibitor of geranylgeranyltransferase I (GGTase I) that selectively disrupts oncogenic K-Ras4B. New study shows that GGTI-286 reduces nuclear localization of β-catenin.

Other Notes

Air sensitive; dessicant.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

(enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service