SRP6155

BMP-2 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

• Synonym(s): BMP-2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in HEK 293 cells
• Assay: ≥95% (SDS-PAGE)
• form: lyophilized
• potency: 20-100 ng/mL ED₅₀
• mol wt: 30-38 kDa (homodimer, glycosylated)
• packaging: pkg of 10 μg
• technique(s): cell culture | mammalian: suitable
• NCBI accession no.: P12643
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... BMP2(650)

Description

General description

BMP2 (bone morphogenetic protein 2) belongs to the transforming growth factor-β (TGFβ) superfamily. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. BioVision′s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.

Application

BMP-2 human has been used to study the biological role of it on adult renal progenitor cells under in vitro and in vivo conditions.

Biochem/physiol Actions

BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. During bone repair, BMP-2 controls the expression of Runt-related transcription factor 2 (Runx2) and Osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis.

Physical form

Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable