Merck
All Photos(1)

Documents

SRP6202

Sigma-Aldrich

ANG-2 human

recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)

Sign Into View Organizational & Contract Pricing

Select a Size

Synonym(s):
ANGPT-2
NACRES:
NA.32

biological source

human

recombinant

expressed in CHO cells

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

60-70 kDa

packaging

pkg of 10 μg
pkg of 50 μg

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ANGPT2(285)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
A9847A0851SRP3007
Sigma-Aldrich

Sigma-Aldrich

SRP6202

ANG-2 human

Sigma-Aldrich

Sigma-Aldrich

A9847

Angiopoietin-2 human

Sigma-Aldrich

Sigma-Aldrich

SRP3007

Angiopoietin-1 human

recombinant

expressed in CHO cells

recombinant

expressed in NSO cells

recombinant

expressed in goat

recombinant

expressed in HeLa cells

assay

≥95% (SDS-PAGE)

assay

>97% (SDS-PAGE)

assay

-

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized

mol wt

60-70 kDa

mol wt

66 kDa by SDS-PAGE (reducing and non-reducing conditions)

mol wt

antigen ~66 kDa

mol wt

60.0-70.0 kDa

packaging

pkg of 10 μg, pkg of 50 μg

packaging

pkg of 25 μg

packaging

-

packaging

pkg of 5 μg

General description

ANG-2 binds to the endothelial cell specific receptor Tie2, but, in contrast to ANG-1 does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie2 and, depending on the physiological and biochemical environment, can act either as a n agonist or antagonist of Tie2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an α helix rich “coiled coil” N-terminal domain and fibrinogen like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer. Recombinant human ANG-2 is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0– 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows an N-terminal sequence starting with residue 68 (D) of the ANG-2 precursor protein.

Physical form

Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 8.0.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service