Merck
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T8158

Sigma-Aldrich

Transferrin human

powder, BioReagent, suitable for cell culture

Synonym(s):
Siderophilin, partially saturated
CAS Number:
EC Number:
MDL number:
NACRES:
NA.75

product line

BioReagent

Quality Level

assay

≥98%

form

powder

concentration

~25 mM

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested
hepatitis and HIV antibody, none detected

solubility

H2O: 50 mg/mL

UniProt accession no.

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... TF(7018)

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General description

Transferrin is a glycoprotein with a branched carbohydrate chain, having two sites for ferric ion binding in its polypeptide chain.

Application

Transferrin human has been used:
  • to incubate human proximal tubule cells (HKC) - 8 cells along with IgG for the examination of albumin specificity
  • as a supplement in serum-containing/devoid medium for human thyroid cell culture
  • as a target glycoprotein to develop an in-gel hydrazinolysis method

Biochem/physiol Actions

Transferrin mediates iron transportation from plasma to cells. The iron-bound transferrin are of three forms: monoferric A/B transferrin and diferric transferrin. The transferrin binds to specific cell surface receptors and are internalized by endocytosis. Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded. Transferrin is known to deliver iron to cells in a physiologically safe and effective form.

Other Notes

Partially iron-saturated

Preparation Note

Heat treated at 60 °C for ten hours.

Analysis Note

Purity by agarose electrophoresis.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

SDS

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