Recombinant adeno-associated virus (AAV)-mediated gene therapy expressing human coagulant factor IX (hF.IX) is a promising gene transfer strategy due to the long-term expression of hF.IX in the liver and weak immune response using a liver-specific promoter. However, in humans and
Malaria caused by Plasmodium species kills more than one million people per year, 90% of them in sub-Saharan Africa. Our previous work had shown that CD8 T cells are a major component of immunity to the first stage of infection
Prenylation is an essential post-translational modification for the proper localization and function of many proteins and is catalyzed by protein farnesyltransferase (FTase) and protein geranylgeranyltransferase type I (GGTase-I). To identify potential novel prenylated proteins, we used a PEPscreen peptide library
Learn about homobifunctional sulfoxide-containing MS-cleavable cross-linkers that enables the capture of protein-protein interactions (PPIs) in native cellular environments, and the identification of cross-linked peptides permits the determination of both identity and connectivity of PPIs.
Peptide stability is impacted by several factors including temperature, moisture content, amino acid composition and sequence. PEPscreen peptides are manufactured and shipped to ensure optimal shelf life.
Proteins are complex biological molecules essential for cellular structure and functions. The majority of proteins commonly interact with various molecules, including other proteins, in order to exert their functions.
Our aim was to investigate the dimerization and activation pattern of two receptors, EGFR (ErbB1) and HER2 (ErbB2), in the EGFR-family using breast cancer cell lines and selected colon tissues as model systems.
Uses for immunofluorescence (IF)—where an antibody conjugated to a molecule that fluoresces when excited by lasers— include protein localization, confirmation of post-translational modification or activation, and proximity to/complexing with other proteins.
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