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Acute and Chronic Inflammation: Microglia in Neuroprotection and Neurodegeneration
The term neurodegeneration characterizes a chronic loss of neuronal structure and function leading to progressive mental impairments.
Nucleotide Synthesis in Cancer Cells
Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA.
ABC Transporters and Cancer Drug Resistance
We presents an article on ABC Transporters and Cancer Drug Resistance
Canonical Wnt / β-Catenin Signaling
We review the Wnt signaling pathway (also, canonical Wnt or beta (β)-catenin pathway) and provide links to related products at sigmaaldrich.com.
β-Adrenoceptors
β-Adrenoceptors are activated either by norepinephrine or epinephrine. Learn more about the role of β-adrenoceptors in protein expression, cell signaling, and metabolism research.
Sensor Dyes
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
Caspases
We offers many products related to caspases for your research needs.
Duolink® Proximity Ligation Assay Instructional Video
This video will show you step-by-step how to perform a Duolink® PLA experiment with cells on a slide that have already been fixed and permeabilized by the user.
c-Src kinase (Csk)
The C-terminal c-Src kinase (Csk) is a 50-kDa cytosolic tyrosine kinase expressed in all examined cell types
Cholecystokinin and Gastrin Receptors
The naturally occurring peptides, cholecystokinin (CCK) and gastrin closely resemble each other at their carboxyl terminus, which is the biologically active portion of the molecules.
Phosphoinositide Kinases
Sigma-Aldrich offers many products related to phosphoinositide kinases for your research needs.
FAK
The focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that distinctly co-localizes with integrins at sites of attachment to their ligands.
Duolink® Proximity Ligation Assay (PLA) Multicolor Kits for Sensitive Multiplex Detection
Duolink® PLA Multicolor technology and the quantification of protein-protein interactions in fixed tissues and cells.
PDGFR
Sigma-Aldrich offers many products related to PDGFR for your research needs.
Glutamine Metabolism is Dysregulated in Many Cancer Cells
Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative
Protein Expression Systems
The development of genetic engineering and cloning has opened many possibilities of expression and isolation of heterologous proteins for research purposes. Considerable advances in technology have enabled expression and isolation of recombinant proteins in large scale.
Ca/CaMKs
Our company offers many products related to Ca/CaMKs for your research needs.
Cyclin-dependent Kinases (CDKs)
Cyclin dependent kinases (CDKs) are typical serine/threonine kinases that display the 11 subdomains shared by all kinases. The complete sequence of the Homo sapiens genome shows that among the ~30,000 predicted genes, there are 13 CDKs and 25 cyclins. Eleven
Dietary Antioxidants
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
Glutamate Receptors (G Protein Family)
Sigma-Aldrich offers many products related to G-protein family glutamate receptors for your research needs.
Chloride Channels
We offer many products related to chloride channels for your research needs.
Glutamate/GABA Synthesis and Metabolism
Glutamine is a common precursor for the biosynthesis of both glutamate and GABA. Glutamine can be transported in and out of neurons and astrocytes utilizing different glutamine carriers. The neurotransmitter glutamate can be synthesized from glutamine by the action of
Overview of G Protein-coupled Receptors (GPCRs)
We offers many products related to GRKs for your research needs.
Nuclear Receptors (Non-Steroids)
We offer many products related to non-steroid nuclear receptors for your research needs.
Understanding Sweet Taste Perception
The powerful effect of the pleasurable sensation arising from sweet tasting foods has led to consumer demand and large-scale production of the caloric sweetening agents sucrose and fructose.
Galanin Receptors
We offer many products related to galanin receptors for your research needs.
GABAB Receptors
We offer many products related to GABAB receptors for your research needs.
GABAA Receptors
We offer many products related to GABAA receptors for your research needs.
Melatonin Receptors
We offer many products related to melatonin receptors for your research needs.
α2-Adrenoceptors
α2-Adrenoceptors
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