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Asymmetric Allylic Alkylation
Palladium-catalyzed asymmetric allylic alkylation (AAA) has proven to be an exceptionally powerful method for the efficient construction of stereogenic centers.
Dess–Martin Periodinane
Dess–Martin periodinane is a reliable and easy-to-use oxidizer in organic synthesis, with advantages such as selectivity, avoiding the use of toxic (i.e. chromium-based) chemicals, using stoichiometric amounts of reagent, and ease of work-up.
Asymmetric Epoxidation Using Shi Catalyst
Catalytic asymmetric epoxidation of alkenes has been the focus of many research efforts over the past two decades, the best known methods probably being those developed by Sharpless and Jacobsen-Katsuki.
KitAlysis High-Throughput Palladium Precatalyst Cross-Coupling Reaction Screening Kit
Materials Included in your KITALYSIS-24PD-2PK High-Throughput Screening Kit
Aerobic Alcohol Oxidation Solutions
Alcohol oxidation is one of the most frequently performed oxidation reactions in organic chemistry. The aldehyde and ketone products of alcohol oxidation are useful intermediates en route to complex molecules.
Privileged structures are a class of molecules that are capable of binding to multiple receptors with high affinity. In order to be considered privileged, a substructure should represent a molecule’s core element and make up a significant portion of its
Copper(I)-mediated Living Radical Polymerization in the Presence of Pyridylmethanimine Ligands
We presents an article about Copper(I)-mediated Living Radical Polymerization in the Presence of Pyridylmethanimine Ligands, and the emergence of living radical polymerization mediated by transition metal catalysts in 1995, which was a seminal piece of work in the field of
KitAlysis™ High-Throughput Copper C-N Cross-Coupling Reaction Screening Kit
Materials included in your KITALYSIS-CUCN-2PK High-Throughput Screening Kit
JandaJels are designed to create a “solvent-like organic microenvironment to catalyze organic reactions”. The flexible tetrahydrofuran-like cross-linker gives the JandaJels increased swelling and solvation characteristics as compared to polystyrene resins cross-linked with divinylbenzene.
Natural Amino Acid Building Blocks for Peptide Synthesis
With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.
The elucidation of a macromolecular structure to the atomic level by X-ray or neutron diffraction analysis requires the molecule to be available in the form of relatively large single crystals. Many soluble proteins, membrane proteins, nucleic acids and nucleoprotein complexes
KitAlysis™ High-Throughput Screening Platform
KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.
Baeyer-Villiger Oxidation Reaction
The Baeyer-Villiger oxidation is the oxidative cleavage of a carbon-carbon bond adjacent to a carbonyl, which converts the ketones to esters and the cyclic ketones to lactones.
Aldehydes - Types & Structure
Technical article regarding Aldehydes - Types & Structure
Lithium Aminoborohydride (LAB) Reagents
Lithium aminoborohydride (LAB) reagents are a new class of powerful and selective reagents developed in the laboratory of Professor Bakthan Singaram at the University of California, Santa Cruz.
Oxidizing and Reducing Agents
Oxidation and reduction reactions are some of the most common transformations encountered in organic synthesis
Task-Specific Ionic Liquids
Task-Specific Ionic Liquids (TSILs) for the selective liquid/liquid extraction of heavy metals from aqueous systems were first published by Robin D. Rogers et al. in the year 2001.
Ugi Reaction
The Ugi reaction (Scheme 1) is an isonitrile-based MCR that provides a rapid route for the preparation of a-aminoacyl amide derivatives. The Ugi 4 component condensation of an amine, oxo compound, carboxylic acid and an isocyanide is the most documented
KitAlysis™ High-Throughput Photocatalysis Reaction Screening Kit
The PhotoKitAlysis Reaction Kit was designed to provide the best possible chance of finding good reaction conditions for cross-coupling reactions: pre-weighed base or base solution (provided), 10–20 mmol coupling partner (user supplied), 10 mmol aryl halide substrate (user supplied), Catalysts
Fluoroalkylation: Expansion of Togni Reagents
The fluoroalkylation toolbox now includes Togni reagents, hypervalent iodine perfluoroalkylation reagents, fluoroalkyl bromides, silanes, carboxylates, and sulfonyl fluorides for late stage fluoroalkylation.
Macmillan Imidazolidinone Organocatalysts
In collaboration with Materia, Inc., we are pleased to offer six imidazolidinone OrganoCatalysts™.
BINOL and Derivatives
We present an article concerning BINOL and Derivatives.
Peroxide Forming Solvents
Information on laboratory solvents that can undergo autoxidation under normal storage conditions to form unstable and potentially dangerous peroxide by-products.
Traditional Strong and Hindered Bases
Evans-Type Auxiliaries
The asymmetric aldol reaction mediated by chiral auxiliaries is considered to be one of the most important methods for asymmetric C-C bond formation.
Tetrakis(dimethylamino)ethylene (TDAE)
In 2001, Professor William Dolbier, Jr., at the University of Florida reported1 an approach to nucleophilic trifluoromethylation based on the generation of a trifluoromethyl anion using CF3I in the presence of a powerful twoelectron reductant, tetrakis(dimethylamino)ethylene (TDAE)
Verkade S Bases
Strong and Hindered Bases in Organic Synthesis
Jacobsen Thioureas
Jacobsen's group have developed a range of chiral thioureas that are versatile, effective organocatalysts.
Maruoka Catalysts
Asymmetric phase transfer catalysis using the Maruoka catalysts has proven to be an ideal method for the enantioselective preparation of natural and unnatural α-alkyl and α,α-dialkyl-α-amino acids from glycine derivati
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