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PromoCell® Primary Cell Pellets
Primary cells from PromoCell are available in pelleted form for research applications like gene expression analysis, and cell/protein characterization experiments.
Preparing Cells for Electroporation
Preparing Cells for Electroporation
LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic
SigmaMab Antibody Drug Conjugate Mimic, is a non-toxic drug mimic utilized as a standard for mass spectrometry and high performance liquid chromatography.
Rapid DNA Ligation Kit Protocol
Rapid DNA Ligation Kit Protocol
DNA Ligation Protocol
The cloning process requires the ligation of linear DNA into a cloning vector. This ability to join fragments of DNA through recombinant technology is essential for many basic experiments in biotechnology.
QuickLink™ DNA Ligation Kit
T4 DNA ligase is used for the joining of DNA molecules with compatible cohesive (sticky) termini, joining of blunt ended double stranded DNA molecules
Polymer Semiconductors for Intrinsically Stretchable Organic Transistors
Intrinsically stretchable active layers for organic field-effect transistors (OFET) are discussed. Polymer structural modification & post-polymerization modifications are 2 methods to achieve this.
Self-Assembled Monolayers: Advantages of Pure Alkanethiols
We presents an article regarding Self-Assembled Monolayers: Advantages of Pure Alkanethiols.
Substituting Strat-M® Membrane for Human Skin in Evaluating Effect of Encapsulation on Diffusion of Sunscreen Formulations
Understand how a Strat-M synthetic membrane model can be an alternative to human or animal skin when screening for effectiveness of encapsulation on reducing transdermal diffusion of skin care actives
Carcinogenesis and Epigenetics
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
Autophagy Mitophagy in Tumor Cell Survival Death
Autophagy is a highly regulated process that is involved in cell growth, development, and death. In autophagy cells destroy their own cytoplasmic components in a very systematic manner and recycle them.
Epigenetic Mechanisms in Cancer Pathogenesis
This page reviews some of our newest and most innovative technologies and their specific applications toward cancer research. One is reminded of how complex the disease of cancer is, and how difficult it is to identify one topic that is
Properties of Mononuclear Cells Isolated by the Ficoll-Paque Method
The effects of the mononuclear cell separation method described by Bøyum procedure are noted below, since research situations may arise in which they are significant.
Nanodisc Technology: A Revolutionary System for Study of Membrane Proteins
Read our article about how the Nanodisc system allows for structural studies of membrane proteins.
Aerobic Alcohol Oxidation Solutions
Alcohol oxidation is one of the most frequently performed oxidation reactions in organic chemistry. The aldehyde and ketone products of alcohol oxidation are useful intermediates en route to complex molecules.
Hematopoietic Stem and Immune Cell Culture
Cryopreserved blood cells and cell culture media for CD34+ human hematopoietic progenitor stem cells, monocytes, PBMCs, macrophages, dendritic and T-cells. Explore over 350 PromoCell products on Sigma.com.
C–H Amination
The Du Bois group at Stanford University has made substantial progress within the field of Rh-catalyzed C–H amination via oxidative cyclization of carbamate, sulfamate, sulfamide, urea, and guanidine substrates to give 1,2- and 1,3-heteroatom motifs masked in the form of
N-Heterocyclic Carbene (NHC) Ligands
Emerging class of privileged ligands
Catalysts for Carbonylation
Professor Geoffrey Coates and co-workers at Cornell University have reported the preparation and use of catalysts composed of an oxophilic Lewis acid and a cobalt tetracarbonyl anion for the ring expansive carbonylation of epoxides to b-lactones and b-lactones to succinic
Improving Reproducibility: Best Practices for Antibodies
In the midst of beeping lab timers, presentations and grant deadlines, it is easy to take for granted the quality of lab reagents.
Extracellular Vesicle Protocol
Best practices for standardizing and reducing the Extracellular Vesicle Preparation workflow, and eliminating contamination of EV preparations with dead-cell-derived vesicles.
Study: Comparison of MC-Media Pad® with Different Convenience Solution Products
Comparison of MC-Media Pad® with different convenience solution products for indicator organism testing
Enzymatic Assay of Superoxide Dismutase
Enzymatic Assay of Superoxide Dismutase
Enzymatic Assay of Trypsin Inhibitor
This technical article described the Enzymatic Assay of Trypsin Inhibitor.
Simple dialysis of Small Volume Samples using V Series Membranes
This article is a protocol for Simple dialysis of small volumes using V Series membranes
Polar Compound Retention using Aqueous Normal-Phase (ANP/HILIC) Chromatography
Polar Compound Retention using Aqueous Normal-Phase (ANP/HILIC) Chromatography
Determination of Headspace Volatiles in Distilled Spirits Using SPME Coupled to GC
In this article, SPME-GC was successfully used to identify many volatile compounds present in the headspace over several spirits.
HPLC Analysis of Aspirin and Salicylic Acid on Ascentis® Express RP-Amide
Separation of Acetylsalicylic acid, analytical standard; Salicylic acid, BioXtra, ≥99.0%
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