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Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.

Journal of aging and health (2013-04-10)
Theodoros Michelakos, Antonis A Kousoulis, Konstantinos Katsiardanis, Nick Dessypris, Anastasia Anastasiou, Kalliopi-Penelopi Katsiardani, Prodromos Kanavidis, Christodoulos Stefanadis, Fotios C Papadopoulos, Eleni Th Petridou
ABSTRACT

To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( > 65 years) residing in Velestino, Greece. Serum measurements and Mini-Mental State Examination (MMSE) assessments were available for 593 Velestinians. In addition, 12 studies availing data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were identified following a search algorithm; pooled effect estimates were derived. Cognitive impairment (MMSE < 24) among Velestenians was associated with lower education level in both genders; decreased social activity, depressive symptoms and low folate levels in males; older age in females. Meta-analyses showed an adverse effect of low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40). Low folate levels are associated with cognitive impairment of seniors; underlying pathophysiological mechanisms should be further explored.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Vitamin B12, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%
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Cyanocobalamin, tested according to Ph. Eur.
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Cyanocobalamin, SAJ special grade, ≥95.0%
Supelco
Cyanocobalamin (Vitamin B12) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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Cyanocobalamin, pharmaceutical secondary standard, certified reference material