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NOTCH2

notch 2

別名:
AGS2, HJCYS, hN2
Species:
UniProtKB ID:
遺伝子ID:
  • Human(4853) Summary: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
  • Mouse(18129) notch 2
  • Rat(29492) notch 2
  • cow(513730) notch 2
  • sheep(101112098) notch 2
  • domestic cat(101091800) notch 2
  • Horse(100067078) notch 2
  • dog(483148) notch 2
  • chicken(374031) notch 2
  • Zebrafish(58065) notch homolog 2
  • domestic guinea pig(100715372) notch 2
  • naked mole-rat(101712759) notch 2

Custom & Knockdown Gene Products

ELISA

製品番号
詳細
Species
Rat Notch-2 ELISA, for serum, plasma and cell culture supernatants,
Species
rat

Antibodies

製品番号
詳細
交差性
アプリケーション
抗Notch 2抗体、NT, serum, from rabbit,
交差性
human, mouse, rat
アプリケーション
ELISA
immunohistochemistry

western blot
Anti-NOTCH2 (Cleaved-Val1697) antibody produced in rabbit, affinity isolated antibody,
交差性
human, mouse, rat
アプリケーション
ELISA
western blot
抗NOTCH2抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
Anti-NOTCH2 (Cleaved-Asp1733) antibody produced in rabbit, affinity isolated antibody,
交差性
human, mouse, rat
アプリケーション
ELISA
immunohistochemistry

western blot
Anti-NOTCH2 (Cleaved-Ala1734) antibody produced in rabbit, affinity isolated antibody,
交差性
human, mouse, rat
アプリケーション
ELISA
western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
DAPT, ≥98% (HPLC), solid,
Species
mouse, human, rat
L-685,458, >96% (HPLC), solid,
Species
mouse, human, rat

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human NOTCH2,
Species
human