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Merck

NOTCH3

notch 3

別名:
CADASIL, CASIL, IMF2
Species:
UniProtKB ID:
遺伝子ID:
  • Human(4854) Summary: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
  • Mouse(18131) notch 3
  • Rat(56761) notch 3
  • domestic guinea pig(100716867) notch 3
  • naked mole-rat(101722220) notch 3
  • Zebrafish(58066) notch homolog 3
  • dog(610439) notch 3
  • domestic cat(101088469) notch 3
  • sheep(101123554) notch 3
  • cow(789485) notch 3

Custom & Knockdown Gene Products

ELISA

製品番号
詳細
Species
Human Notch-3 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

製品番号
詳細
交差性
アプリケーション
Anti-NOTCH 3/N3ECD Antibody, clone 1E4, clone 1E4, 1 mg/mL, from mouse,
交差性
human
アプリケーション
electron microscopy
immunocytochemistry

western blot
抗NOTCH3抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
Anti-Notch 3 Antibody, clone 1G17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
交差性
human, mouse, rat
アプリケーション
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Monoclonal Anti-NOTCH3 antibody produced in mouse, clone 2E2, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
ELISA
immunofluorescence

western blot
Anti-Notch3 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence

Small Molecule - Inhibitor

製品番号
詳細
Species
DAPT, ≥98% (HPLC), solid,
Species
mouse, human, rat
L-685,458, >96% (HPLC), solid,
Species
mouse, human, rat

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human NOTCH3,
Species
human
MISSION® esiRNA, targeting mouse Notch3,
Species
mouse