コンテンツへスキップ
Merck

PRKACB

protein kinase, cAMP-dependent, catalytic, beta

別名:
PKACB
Species:
UniProtKB ID:
遺伝子ID:
  • Human(5567) Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2011]
  • Mouse(18749) protein kinase, cAMP dependent, catalytic, beta
  • Rat(293508) protein kinase, cAMP dependent, catalytic, beta
  • dog(479975) protein kinase, cAMP-dependent, catalytic, beta
  • chicken(424542) protein kinase, cAMP-dependent, catalytic, beta
  • naked mole-rat(101721558) protein kinase, cAMP-dependent, catalytic, beta
  • cow(282323) protein kinase, cAMP-dependent, catalytic, beta
  • domestic cat(101095353) protein kinase, cAMP-dependent, catalytic, beta
  • sheep(101108785) protein kinase, cAMP-dependent, catalytic, beta
  • Zebrafish(100538234) protein kinase, cAMP-dependent, catalytic, beta
  • domestic guinea pig(100712694) protein kinase, cAMP-dependent, catalytic, beta

Custom & Knockdown Gene Products

Antibodies

製品番号
詳細
交差性
アプリケーション
Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody, Upstate®, from rabbit,
交差性
mouse
アプリケーション
western blot
Anti-PRKACB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
Anti-phospho-PKA CAT (pThr197) antibody produced in rabbit, affinity isolated antibody,
交差性
human, mouse, rat
アプリケーション
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-phospho-PKA C (Thr197) Antibody, clone 24GB1650, Rabbit Monoclonal, clone 24GB1650, recombinant rabbit monoclonal, expressed in HEK293 cells,
交差性
human, rat
アプリケーション
flow cytometry
western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
ヒスピジン, solid, ≥98% (HPLC),
Species
human
GSK690693, ≥98% (HPLC),
Species
human

Proteins

製品番号
詳細
Species
プロテインキナーゼ A 触媒サブユニットβ, 活性型 ヒト, recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
プロテインキナーゼ A ウシ心臓由来, ≥0.8 units/μg protein, lyophilized powder,
Species
cow

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human PRKACB,
Species
human
MISSION® esiRNA, targeting mouse Prkacb,
Species
mouse