The maximum flow rate for this microfluidic product has not been tested. However, it is suggested to set the flow rate to 100 μL/min. The maximum backpressure has not been specified.
911593
NanoFabTx™ microfluidic - nano
device kit for synthesis of 100-200 nm nanoparticles and liposomes
別名:
Liposomes, Microfluidic kit, NanoFabTx™ device kit, Nanoformulation, Nanoparticle
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￥497,000
About This Item
UNSPSCコード:
12162002
UNSPSCコード:
41121811
NACRES:
NA.23
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詳細
Microfludic device kit for synthesizing nanparticles
Kit components :
- Microfluidic chip x 1
- Tubings and accessories
品質水準
アプリケーション
advanced drug delivery
詳細
NanoFabTx™ Microfluidic - nano device kit is a set of plug-and-play, easy-to-use microfluidic components that are compatible with Dolomite microfluidic systems and standard syringe pumps (not included). The device kit can be combined with our special nanoformulation kits (please visit www.sigmaaldrich.com/nanofabtx) to form nanoparticles or liposomes 100 to 200 nm in size. The device kit includes a comprehensive protocol, pre-assembled microfluidic chip manifold, tubing, and required accessories.
アプリケーション
NanoFabTx™ Microfluidic - nano device kit is designed to work with NanoFabTx™ - nano reagent kits (including 909637, 918075, and 907766) to synthesize drug-encapsulating liposome nanoparticles (LNP) and drug-encapsulating polymeric nanoparticles for targeted drug delivery research. Our device kit simplifies LNP formulation and polymeric nanoformulation by leveraging microfluidic technologies to achieve narrow size dispersity and high batch-to-batch consistency. The microfluidic chip manifold is chemically robust and compatible with a variety of solvents and therapeutics relevant in nanomedicine. The microfluidic chip geometries and controllable flow enable the user to achieve targetable particle diameters with homogenous shape and structure from 100 to 200 nm in size. By enabling users to easily fine-tune the synthetic parameters, our microfluidic-based tool allows scalable synthesis of drug-encapsulating nanocarriers for researchers in the field of precision medicine, drug discovery, and nanoparticle cancer treatment.
特徴および利点
- Step-by-step microfluidic-based protocols developed and tested by our formulation scientists
- Optimization of drug encapsulation and loading efficiency in nanoparticles and liposomes
- Selection of optimal nanoparticle and liposome size of any size between 100-200 nm
- Small reaction volumes to reduce waste of expensive reagents and therapeutics
法的情報
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
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最新バージョンのいずれかを選択してください：
Samar Damiati et al.
Genes, 9(2) (2018-02-22)
Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow
Xuanyu Li et al.
Advanced drug delivery reviews, 128, 101-114 (2017-12-27)
Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct properties by changing the precursors and the flow rates, significantly decreasing the time for screening optimal formulation as carriers for drug delivery compared to conventional methods.
Andrew Gdowski et al.
Journal of nanobiotechnology, 16(1), 12-12 (2018-02-13)
The process of optimization and fabrication of nanoparticle synthesis for preclinical studies can be challenging and time consuming. Traditional small scale laboratory synthesis techniques suffer from batch to batch variability. Additionally, the parameters used in the original formulation must be
資料
NanoFabTx™ platform accelerates drug development with ready-to-use formulations and microfluidic devices for particle synthesis.
NanoFabTx™プラットフォームは、すぐに使用できる製剤と粒子合成のためのマイクロ流体デバイスにより、薬剤開発を加速させます。
NanoFabTX kits enable precise drug delivery with lipid nanoparticles and liposomes for mRNA and nucleic acids.
NanoFabTXキットは、mRNAや核酸用の脂質ナノ粒子やリポソームによる正確な薬物送達を可能にします。
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What is the maximum flowrate that the microfluidic, 911593, can take or the maximum backpressure of the fluidics?
1 回答-
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How can I determine the shelf life / expiration / retest date of this product?
1 回答-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf役に立ちましたか？
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 回答-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Me podrían indicar si los chips son de un solo uso o reciclables? Cuántos chips entran en el kit?
1 回答-
This product includes 1 chip and the additional tubing, valves, and accessories required for use. The kit components, including the chip, are reusable. However, proper cleaning is required. Please see the link below to review the product usage instructions, including the cleaning protocol:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/105/115/911593pis-ms.pdf役に立ちましたか？
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Can more information be provided on the material of construction for NanoFabTx microfluidic chip product 911593? Additionally, is this product compatible with ethyl acetate?
1 回答-
Regarding fluidic compatibility, the most effective approach to address this question is for a review of the fluidic pathway involved, after which compatibility can be verified. The components are as follows:
1.Tubing: PTFE/FEP – Resistant (A)
2.Chip: B270 Crown Glass – Resistant (A)
3.Linear Connector: PEEK – Resistant (A)
4.Linear Connector Seal: FFKM – Resistant (A)
5.Linear Connector Screws: Stainless Steel (316) - Resistant (B)
6.H-Interface: Aluminum - Resistant (A)
In general, the flow path demonstrates excellent resistance to ethyl acetate. It is advisable to flush the flow path with DI Water/IPA (filtered) before introducing a target solvent to ensure that the fluidic pathway is properly sealed and not leaking prior to use. Additionally, once the process is complete, flushing the solvent out of the system is recommended to ensure cleanliness and dryness.役に立ちましたか？
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アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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