Merck

700016P

Avanti

cholesterol sulfate

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別名:
cholesterol sulfonate; cholesteryl sulfate; sodium cholesteryl sulfate; cholesteryl sulphate
Empirical Formula (Hill Notation):
C27H45NaO4S
CAS番号:
分子量:
488.70
NACRES:
NA.25

詳細

cholesterol 3-sulfate (sodium salt)

アッセイ

>99% (TLC)

形状

powder

包装

pkg of 1 × 1 g (700016P-1g)
pkg of 1 × 25 mg (700016P-25mg)
pkg of 1 × 500 mg (700016P-500mg)

manufacturer/tradename

Avanti Polar Lipids 700016P

輸送温度

dry ice

保管温度

−20°C

InChI

1S/C27H46O4S.Na/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(31-32(28,29)30)13-15-26(20,4)25(22)14-16-27(23,24)5;/h9,18-19,21-25H,6-8,10-17H2,1-5H3,(H,28,29,30);/q;+1/p-1/t19-,21+,22+,23-,24+,25+,26+,27-;/m1./s1

InChI key

LMPVQXVJTZWENW-KPNWGBFJSA-M

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当該品目
700187P700192P700032P
cholesterol sulfate

Avanti

700016P

cholesterol sulfate

ox-18:2 Cholesterol powder

Avanti

700192P

ox-18:2 Cholesterol

5α,6α-epoxycholestanol Avanti Polar Lipids

Avanti

700032P

5α,6α-epoxycholestanol

form

powder

form

powder

form

powder

form

powder

packaging

pkg of 1 × 1 g (700016P-1g), pkg of 1 × 25 mg (700016P-25mg), pkg of 1 × 500 mg (700016P-500mg)

packaging

pkg of 1 × 100 mg (700187P-100MG), pkg of 1 × 5 mg (700187P-5MG)

packaging

package of 1 × 500 μg (700192P-500UG)

packaging

pkg of 1 × 5 mg (700032P-5mg)

manufacturer/tradename

Avanti Polar Lipids 700016P

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

詳細

Cholesterol sulfate is synthesized by the sulfoconjugation of cholesterol in the presence of enzyme cholesterol sulfotransferase. It is present in brain, lungs, hair and skin tissues as well as cells including erythrocytes, platelets and spermatozoa.

アプリケーション

Cholesterol sulfate has been used in micelle preparation and in surface plasmon resonance (SPR) studies.

生物化学的/生理学的作用

Cholesterol sulfate is associated with atherosclerotic lesions and serves as a substrate for platelet adhesion. It stabilizes the spermatozoa membranes and erythrocytes. Cholesterol sulfate is involved in the keratinocyte differentiation and its levels are elevated in recessive X-linked ichthyosis. It serves as a ligand for retinoic acid-related orphan receptor α (RORα). Cholesterol sulfate regulates glucose metabolism and is a potential target for metabolic disorders. It is also a potential marker for human uterine cervical carcinoma tissue and prostate carcinoma.

包装

20 mL Clear Glass Screw Cap Vial (700016P-1g)
20 mL Clear Glass Screw Cap Vial (700016P-500mg)
5 mL Amber Glass Screw Cap Vial (700016P-25mg)

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


Certificates of Analysis (COA)

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製品番号
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25G
容量/数量

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

以下のように入力してください 1.000309185)

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  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

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DC-Cholesterol HCl Avanti Polar Lipids 700001P, powder

Avanti

700001P

DC-コレステロールHCl

18:1 PA Avanti Polar Lipids

Avanti

840875P

18:1 PA

Cholesterol solution certified reference material, 10 mg/mL in chloroform

Supelco

47127-U

コレステロール 溶液

Oleylamine technical grade, 70%

Sigma-Aldrich

O7805

オレイルアミン

Patrizia Lopalco et al.
Frontiers in physiology, 10, 1344-1344 (2019-11-19)
The reduction of sperm motility and count, or oligoasthenozoospermia, is one of the major causes of reduced fertility or infertility in men. Lipid composition of spermatozoa is important in determining their functional characteristics, in particular on motility, acrosomal exocytosis or
M Merten et al.
Circulation, 103(16), 2032-2034 (2001-04-25)
Cholesterol 3-sulfate is present on a variety of cells and in human LDL, and it has been found in atherosclerotic lesions of human aorta. Its precise biological role has not yet been described. In this study, we investigated the interaction
Charles A Strott et al.
Journal of lipid research, 44(7), 1268-1278 (2003-05-06)
Cholesterol sulfate is quantitatively the most important known sterol sulfate in human plasma, where it is present in a concentration that overlaps that of the other abundant circulating steroid sulfate, dehydroepiandrosterone (DHEA) sulfate. Although these sulfolipids have similar production and
Alexey V Kostarnoy et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(13), E2758-E2765 (2017-03-16)
Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases. The evolutionarily conserved innate immune system is considered to play a key role in tissue injury recognition and the subsequent development of sterile inflammation;
Xiongjie Shi et al.
Molecular and cellular biology, 34(3), 485-497 (2013-11-28)
Sulfotransferase (SULT)-mediated sulfation represents a critical mechanism in regulating the chemical and functional homeostasis of endogenous and exogenous molecules. The cholesterol sulfotransferase SULT2B1b catalyzes the sulfoconjugation of cholesterol to synthesize cholesterol sulfate (CS). In this study, we showed that the

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