700026P

3β-hydroxy-7-oxo-5-cholestenoic acid

Avanti Polar Lipids

• 別名: (25R)-cholest-5-en-26-oic acid, 3β-hydroxy-7-oxo
• Empirical Formula (Hill Notation): C₂₇H₄₂O₄
• CAS番号: 1246298-64-5
• 分子量: 430.62
• NACRES: NA.25

特性

• アッセイ: >99% (TLC)
• 形状: powder
• 包装: pkg of 1 × 5 mg (700026P-5mg)
• manufacturer/tradename: Avanti Polar Lipids
• 輸送温度: dry ice
• 保管温度: −20°C

詳細

詳細

Cholestenoic acids are cholesterol metabolic intermediates and precursors to bile acids. 3β-hydroxy-7-oxo-5-cholestenoic acid is synthesized from 7β-hydroxycholesterol. The enzymes for synthesis of cholestenoic acids are majorly present in the central nervous system (CNS) of mammals. 3β-hydroxy-7-oxo-5-cholestenoic acid (3βH,7O-CA) is also synthesized from 26-hydroxy-7-oxocholesterol by the action of the enzyme cytochrome P450 family 27 subfamily A member 1 sterol 27-hydroxylase (CYP27A1).

生物化学的／生理学的作用

3β-hydroxy-7-oxocholest-5-en-26-oic acid (3βH,7O-CA) acts as a ligand for liver X receptors (LXR) and activates them at micromolar concentration. 3βH,7O-CA favors the islet-1⁺ cells synthesis and islet-1–GFP expression. 3βH,7O-CA also mediates oculomotor neurons maturation and its conversion to 3β,7β-dihydroxycholest-5-en-(25S)26-oic acid (3β,7β-diHCA) is catalyzed by the enzyme hydroxysteroid 11-β dehydrogenase.

包装

5 mL Amber Glass Screw Cap Vial (700026P-5mg)

安全性情報

• 保管分類コード: 11 - Combustible Solids