Merck
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資料

700027P

Avanti

7α-hydroxy-3-oxo-4-cholestenoic acid

Avanti Polar Lipids

すべての画像(2)
別名:
(25R)-cholest-4-en-26-oic acid, 7α-hydroxy-3-oxo
Empirical Formula (Hill Notation):
C27H42O4
CAS番号:
1246298-65-6
分子量:
430.62
NACRES:
NA.25

アッセイ

>99% (TLC)

形状

powder

包装

pkg of 1 × 1 mg (700027P-1mg)

manufacturer/tradename

Avanti Polar Lipids

輸送温度

dry ice

保管温度

−20°C

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当該品目
700029P700133P700083P
7α-hydroxy-3-oxo-4-cholestenoic acid Avanti Polar Lipids

Avanti

700027P

7α-hydroxy-3-oxo-4-cholestenoic acid

3β,7β-dihydroxy-5-cholestenoic acid Avanti Polar Lipids

Avanti

700029P

3β,7β-dihydroxy-5-cholestenoic acid

3β,25-OH-7-oxo-5-cholestenoic acid Avanti Polar Lipids 700133P, powder

Avanti

700133P

3β,25-OH-7-oxo-5-cholestenoic acid

3-oxo-4-cholestenoic acid Avanti Polar Lipids

Avanti

700083P

3-oxo-4-cholestenoic acid

form

powder

form

powder

form

powder

form

powder

packaging

pkg of 1 × 1 mg (700027P-1mg)

packaging

pkg of 1 × 1 mg (700029P-1mg)

packaging

pkg of 1 × 1 mg (700133P-1mg)

packaging

pkg of 1 × 1 mg (700083P-1mg)

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids 700133P

manufacturer/tradename

Avanti Polar Lipids

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

詳細

7α-Hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) is synthesized extrahepatically from cholesterol. The enzyme oxysterols-7α-hydrolase (CYP7B1) acts on precursor 27-hydroxycholesterol (27-OHC) to generate 7-HOCA.. 7-HOCA is catabolized in the liver.

アプリケーション

7α-hydroxy-3-oxo-4-cholestenoic acid has been used as an analyte in ultra-high-performance liquid chromatography (UHPLC) system.

生物化学的／生理学的作用

The levels of 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) in cerebrospinal fluid are not correlated to neurodegeneration but may serve as a diagnostic marker to trace blood-brain barrier integrity.

包装

5 mL Amber Glass Screw Cap Vial (700027P-1mg)

保管分類コード

11 - Combustible Solids

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Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich製品

  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

  • もし05427ES-021などの充てんコード付きロット番号を見つけた場合は、充てんコードの-021を除いたロット番号05427ESを入力します。

  • もしSTBB0728K9などの充てんコード付きロット番号を見つけた場合は、充てんコードのK9を除いたロット番号STBB0728を入力します。

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Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome
Madenspacher JH, et al.
The Journal of Allergy and Clinical Immunology, 143(1), 440-442 (2019)
Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
Shafaati M, et al.
Journal of Lipid Research, 52(5), 1004-1010 (2011)
Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation
Testa G, et al.
Redox Biology, 10, 24-33 (2016)
7 ? -hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier
Saeed A, et al.
Journal of Lipid Research, 55(2), 313-318 (2014)
Vladimiro Cardenia et al.
Biochimie, 153, 99-108 (2018-08-06)
The electronic cigarettes (e-cigarettes, e-cigs) have become the most sought-after alternative to the traditional cigarettes, partly due to the widespread perception of safety. However, the high temperature reached by e-cig solutions can generate toxic compounds, some of which are listed

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