Merck
すべての画像(2)

資料

700042P

Avanti

4β-hydroxycholesterol-d7

Avanti Polar Lipids

すべての画像(2)
別名:
cholest-5-ene-3b,4b-diol(d7)
Empirical Formula (Hill Notation):
C27H39O2D7
CAS番号:
1246302-80-6
分子量:
409.70
NACRES:
NA.25

詳細

cholest-5-ene-3,4-diol-d7

アッセイ

>99% (TLC)

形状

powder

包装

pkg of 1 × 1 mg (700042P-1mg)

manufacturer/tradename

Avanti Polar Lipids

輸送温度

dry ice

保管温度

−20°C

InChI

1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1/i1D3,2D3,17D

InChI key

CZDKQKOAHAICSF-BZNWTYAPSA-N

類似品目との比較

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当該品目
700044P700014P700043P
4β-hydroxycholesterol-d7 Avanti Polar Lipids

Avanti

700042P

4β-hydroxycholesterol-d7

7β-hydroxycholesterol-d7 Avanti Polar Lipids

Avanti

700044P

7β-hydroxycholesterol-d7

5β,6β-epoxycholestanol-d7 Avanti Polar Lipids

Avanti

700014P

5β,6β-epoxycholestanol-d7

7α-hydroxycholesterol-d7 Avanti Polar Lipids

Avanti

700043P

7α-hydroxycholesterol-d7

form

powder

form

powder

form

powder

form

powder

packaging

pkg of 1 × 1 mg (700042P-1mg)

packaging

pkg of 1 × 1 mg (700044P-1mg)

packaging

pkg of 1 × 1 mg (700014P-1mg)

packaging

pkg of 1 × 1 mg (700043P-1mg)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

description

cholest-5-ene-3,4-diol-d7

description

cholest-5-en-3β,7β-diol-d7

description

cholestanol, 5β,6β-epoxy-d7

description

cholest-5-en-3β,7α-diol-d7

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

詳細

4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol.

アプリケーション

4β-hydroxycholesterol-d7 has been used:
  • as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
  • to spike serum samples for mass spectrometry measurements
  • as an internal standard for the quantification of human colon biopsies samples using HPLC-MS

生物化学的／生理学的作用

4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand. The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation.

包装

5 mL Amber Glass Screw Cap Vial (700042P-1mg)

保管分類コード

11 - Combustible Solids

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  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

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COAをリクエストする

Owein Guillemot-Legris et al.
Journal of Crohn's & colitis, 13(2), 218-229 (2018-10-09)
Inflammatory bowel diseases [IBD] represent a challenging health issue with a complex aetiology involving genetic and environmental parameters. Although our understanding of the pathophysiology of IBD has improved, much remains to be explored. In this context, bioactive lipids, more specifically
Mahmoud Hasan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1033-1034, 193-199 (2016-08-28)
Cytochrome P450 3A (CYP) enzymes are involved in the elimination of many drugs and are known to be regulated by several environmental factors. Thus, it was the aim of this study to develop and validate an analytical method allowing estimation
Sarah J Woolsey et al.
Basic & clinical pharmacology & toxicology, 118(4), 284-291 (2015-09-25)
Due to high basal interindividual variation in cytochrome P450 3A (CYP3A) activity and susceptibility to drug interactions, there has been interest in the application of efficient probe drug phenotyping strategies, as well as endogenous biomarkers for assessment of in vivo

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