Merck
すべての画像(2)

資料

700044P

Avanti

7β-hydroxycholesterol-d7

Avanti Polar Lipids

すべての画像(2)
別名:
cholest-5-ene-3b,7b-diol(d7)
Empirical Formula (Hill Notation):
C27H39O2D7
CAS番号:
349553-97-5
分子量:
409.70
NACRES:
NA.25

詳細

cholest-5-en-3β,7β-diol-d7

アッセイ

>99% (TLC)

形状

powder

包装

pkg of 1 × 1 mg (700044P-1mg)

manufacturer/tradename

Avanti Polar Lipids

輸送温度

dry ice

保管温度

−20°C

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当該品目
700042P700014P700043P
7β-hydroxycholesterol-d7 Avanti Polar Lipids

Avanti

700044P

7β-hydroxycholesterol-d7

4β-hydroxycholesterol-d7 Avanti Polar Lipids

Avanti

700042P

4β-hydroxycholesterol-d7

5β,6β-epoxycholestanol-d7 Avanti Polar Lipids

Avanti

700014P

5β,6β-epoxycholestanol-d7

7α-hydroxycholesterol-d7 Avanti Polar Lipids

Avanti

700043P

7α-hydroxycholesterol-d7

form

powder

form

powder

form

powder

form

powder

packaging

pkg of 1 × 1 mg (700044P-1mg)

packaging

pkg of 1 × 1 mg (700042P-1mg)

packaging

pkg of 1 × 1 mg (700014P-1mg)

packaging

pkg of 1 × 1 mg (700043P-1mg)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

description

cholest-5-en-3β,7β-diol-d7

description

cholest-5-ene-3,4-diol-d7

description

cholestanol, 5β,6β-epoxy-d7

description

cholest-5-en-3β,7α-diol-d7

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

詳細

7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol. 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.

アプリケーション

7β-hydroxycholesterol-d7 has been used:
  • as cholesterol oxidation product for mass spectroscopy analysis
  • as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis
  • as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry
  • as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification

生物化学的／生理学的作用

7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.

包装

5 mL Amber Glass Screw Cap Vial (700044P-1mg)

保管分類コード

11 - Combustible Solids

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  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

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Virginie Aires et al.
Scientific reports, 9(1), 9134-9134 (2019-06-27)
Obesity may not be consistently associated with metabolic disorders and mortality later in life, prompting exploration of the challenging concept of healthy obesity. Here, the consumption of a high-fat/high-sucrose (HF/HS) diet produces hyperglycaemia and hypercholesterolaemia, increases oxidative stress, increases endotoxaemia
Guilherme Silva Ferreira et al.
Frontiers in physiology, 8, 644-644 (2017-09-21)
Background: Oxysterols are bioactive lipids that control cellular cholesterol synthesis, uptake, and exportation besides mediating inflammation and cytotoxicity that modulate the development of atherosclerosis. Aerobic exercise training (AET) prevents and regresses atherosclerosis by the improvement of lipid metabolism, reverse cholesterol
Zoltán Pataj et al.
Journal of chromatography. A, 1439, 82-88 (2015-11-27)
Oxysterols are important intermediates in numerous metabolic and catabolic pathways and their biological significance is also proven. The present paper describes a reliable and short liquid chromatography-high-resolution mass spectrometry method (LC-MS/HR-MS) for the quantification of 8 different oxysterols (24(S)-hydroxycholesterol, 25-hydroxycholesterol
Changguang Wang et al.
International journal of pharmaceutics, 569, 118576-118576 (2019-07-31)
Cholesterol is one of the major structural constituents in a liposomal bilayer. Cholesterol is susceptible to various reactions in the presence of oxygen, heat, light, certain metals, and radicals during manufacturing or storage, which may cause to generate cholesterol oxidation
Sonja Kunz et al.
The Journal of steroid biochemistry and molecular biology, 190, 99-103 (2019-03-30)
The human gut microbiome plays a crucial role in both health and disease. Metabolites in human faeces related to microbial activity might therefore be attractive surrogate markers to track changes of microbiota induced by diet or disease. The hyphenation of
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