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Merck

700046P

Avanti

7-ketocholesterol-d7

Avanti Research™ - A Croda Brand

別名:

3b-hydroxy-5-cholestene-7-one(d7); 7-Oxocholesterol(d7); 7-oxo-5-Cholesten-3b-ol-7-one(d7); 5-cholesten-3 b-ol-7-one(d7); 3b-Hydroxycholest-5-en-7-one(d7)

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1 MG

￥114,000

￥114,000

本日発送予定詳細

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この商品について

実験式（ヒル表記法）:
C27H37O2D7
CAS番号:
127684-08-6
分子量:
407.68
MDL number:
MFCD06658677
UNSPSC Code:
12352100
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
powder

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SMILES string

O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@](C(CC4)[C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C)(CC3)C)C(=O)C=C2C1)C

InChI

1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18-,20+,21?,22+,23+,25+,26+,27-/m1/s1/i1D3,2D3,17D

InChI key

YIKKMWSQVKJCOP-YMQSFMNJSA-N

description

3β-hydroxy-5-cholestene-7-one-d7

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700046P-1mg), pkg of 1 × 5 mg (700046P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

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当該品目
700044P700041P700042P
7-ketocholesterol-d7 Avanti Research™ - A Croda Brand

Avanti

700046P

7-ketocholesterol-d7

7β-hydroxycholesterol-d7 Avanti Research™ - A Croda Brand

Avanti

700044P

7β-hydroxycholesterol-d7

cholesterol-d7 Avanti Research™ - A Croda Brand

Avanti

700041P

cholesterol-d7

4β-hydroxycholesterol-d7 Avanti Research™ - A Croda Brand

Avanti

700042P

4β-hydroxycholesterol-d7

assay

>99% (TLC)

assay

>99% (TLC)

assay

>99% (TLC)

assay

>99% (TLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

packaging

pkg of 1 × 1 mg (700046P-1mg), pkg of 1 × 5 mg (700046P-5mg)

packaging

pkg of 1 × 1 mg (700044P-1mg)

packaging

pkg of 1 × 10 mg (700041P-10mg), pkg of 1 × 200 mg (700041P-200mg), pkg of 1 × 25 mg (700041P-25mg), pkg of 1 × 50 mg (700041P-50mg)

packaging

pkg of 1 × 1 mg (700042P-1mg)

description

3β-hydroxy-5-cholestene-7-one-d7

description

cholest-5-en-3β,7β-diol-d7

description

-

description

cholest-5-ene-3,4-diol-d7

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand

General description

7-ketocholesterol-d7 is a deuterated derivative of 7-ketocholesterol. 7-ketocholesterol is a cholesterol autooxidation product.[1]

Application

7-ketocholesterol-d7 has been used:
  • as a deuterated internal standard for spiking plasma samples for liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis[2]
  • as a deuterated internal standard for spiking aorta and macrophage lipid extract gas chromatography-mass spectrometry (CG/MS)[3]
  • as an internal standard in ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) for plasma oxysterol analysis[4]

Biochem/physiol Actions

7-ketocholesterol (7-KC) levels are elevated in cerebrospinal fluid in multiple sclerosis, senile cataracts, in erythrocytes of sickle cell anemia[1] and in hypercholesterolemia.[5] 7-KC favors apoptosis in macrophages and is involved in endoplasmic reticulum stress.[6] 7-KC is also implicated in liver damage and Niemann Pick disease.[6]

Packaging

5 mL Amber Glass Screw Cap Vial (700046P-1mg)
5 mL Amber Glass Screw Cap Vial (700046P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

保管分類

11 - Combustible Solids

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

700046P-VAR: + 700046P-5MG: + 700046P-1MG: + 700046P-BULK:

jan

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試験成績書（COA）

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

David M van Reyk et al.
Redox report : communications in free radical research, 11(6), 255-262 (2007-01-09)
Oxysterols are the 27-carbon products of cholesterol oxidation by both enzymic and non-enzymic mechanisms. Their roles in cholesterol homeostasis, as well as in diseases in which oxidative damage and lipid peroxidation are implicated (e.g. atherosclerosis), have been investigated extensively. However
Amelia Anderson et al.
Redox biology, 29, 101380-101380 (2020-01-14)
7-Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and disabilities of aging, as well as several orphan diseases. 7KC is the most common product of a reaction between cholesterol and oxygen radicals and is the most
Jiayi Song et al.
Circulation research, 120(10), 1622-1631 (2017-04-07)
7-Ketocholesterol (7-KC), a form of cholesterol oxidation product, plays an essential role in the atherogenesis in animal models. We sought to determine the association of circulating 7-KC with clinical cardiovascular outcomes and total mortality in patients with stable coronary artery
Irundika H K Dias et al.
Redox biology, 16, 139-145 (2018-03-04)
Oxysterols (OHC) are biologically active cholesterol metabolites circulating in plasma that may be formed enzymatically (e.g. 24S-OHC, 25-OHC and 27-OHC) or by autoxidative mechanisms (e.g. 7-ketocholesterol, 7β-OHC and 25-OHC). Oxysterols are more soluble than cholesterol and are reported to exert
M Voorink-Moret et al.
Molecular genetics and metabolism, 123(2), 76-84 (2018-01-02)
In patients suspected of a lipid storage disorder (sphingolipidoses, lipidoses), confirmation of the diagnosis relies predominantly on the measurement of specific enzymatic activities and genetic studies. New UPLC-MS/MS methods have been developed to measure lysosphingolipids and oxysterols, which, combined with
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