Merck
すべての画像(2)

資料

700047P

Avanti

5α,6α-epoxycholestanol-d7

Avanti Polar Lipids

すべての画像(2)
別名:
cholestanol, 5α,6α-epoxy-d7
Empirical Formula (Hill Notation):
C27H39O2D7
CAS番号:
127685-38-5
分子量:
409.70
NACRES:
NA.25

アッセイ

>99% (TLC)

形状

powder

包装

pkg of 1 × 1 mg (700047P-1mg)

manufacturer/tradename

Avanti Polar Lipids

輸送温度

dry ice

保管温度

−20°C

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当該品目
700014P700042P700055P
5α,6α-epoxycholestanol-d7 Avanti Polar Lipids

Avanti

700047P

5α,6α-epoxycholestanol-d7

5β,6β-epoxycholestanol-d7 Avanti Polar Lipids

Avanti

700014P

5β,6β-epoxycholestanol-d7

4β-hydroxycholesterol-d7 Avanti Polar Lipids

Avanti

700042P

4β-hydroxycholesterol-d7

5α,6β-dihydroxycholestanol-d7 Avanti Polar Lipids

Avanti

700055P

5α,6β-dihydroxycholestanol-d7

form

powder

form

powder

form

powder

form

powder

packaging

pkg of 1 × 1 mg (700047P-1mg)

packaging

pkg of 1 × 1 mg (700014P-1mg)

packaging

pkg of 1 × 1 mg (700042P-1mg)

packaging

pkg of 1 × 1 mg (700055P-1mg), pkg of 1 × 5 mg (700055P-5mg)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

詳細

5α,6α-epoxycholestanol (5α,6α-EC) is generated by cholesterol epoxidation. 5α,6α-epoxycholestanol-d7 is a deuterated derivative of 5α,6α-EC. It is catabolized by the enzyme cholesterol-5,6-epoxide hydrolase (ChEH) enzyme to 3β,5α,6β-triol.

アプリケーション

5α,6α-epoxycholestanol-d7 has been used as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondrial samples. It may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma samples.

生物化学的／生理学的作用

5α,6α-epoxycholestanol (5α,6α-EC) is a liver X receptor (LXR) antagonist. 5α,6α-EC is employed in anticancer treatments. It impairs redox state and affects atherogenesis. The levels of 5α,6α-EC are elevated in hypercholesterolemia. It mediates steroid receptor coactivator (SRC) recruitment.

包装

5 mL Amber Glass Screw Cap Vial (700047P-1mg)

よく一緒に購入される製品

製品番号
詳細
価格

保管分類コード

11 - Combustible Solids

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  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

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5alpha, 6alpha-Epoxyphytosterols and 5alpha, 6alpha-Epoxycholesterol Increase Oxidative Stress in Rats on Low-Cholesterol Diet
Wielkoszynski T, et al
Oxidative Medicine and Cellular Longevity, 2019 (2019)
Regis Soules et al.
Chemistry and physics of lipids, 207(Pt B), 92-98 (2017-05-31)
5,6α-epoxycholesterol (5,6α-EC) and 5,6β-epoxycholesterol (5,6β-EC) are oxysterols involved in the anticancer pharmacology of the widely used antitumor drug tamoxifen. They are both metabolized into cholestane-3β,5α,6β-triol (CT) by the cholesterol-5,6-epoxide hydrolase (ChEH) enzyme, and CT is metabolized by an as-yet uncharacterized
Thomas J Berrodin et al.
Molecular pharmacology, 78(6), 1046-1058 (2010-09-15)
The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor superfamily that function as key transcriptional regulators of a number of biological processes, including cholesterol homeostasis, lipid metabolism, and keratinocyte differentiation. Natural ligands that activate LXRs include
Julien Musman et al.
Biochemical pharmacology, 142, 87-95 (2017-06-25)
A major cause of cell death during myocardial ischemia-reperfusion is mitochondrial dysfunction. We previously showed that the reperfusion of an ischemic myocardium was associated with an accumulation of cholesterol into mitochondria and a concomitant strong generation of auto-oxidized oxysterols. The
Myung-Jin Oh et al.
Journal of lipid research, 57(5), 791-808 (2016-03-19)
Endothelial biomechanics is emerging as a key factor in endothelial function. Here, we address the mechanisms of endothelial stiffening induced by oxidized LDL (oxLDL) and investigate the role of oxLDL in lumen formation. We show that oxLDL-induced endothelial stiffening is

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