Merck
すべての画像(2)

資料

700055P

Avanti

5α,6β-dihydroxycholestanol-d7

Avanti Polar Lipids

すべての画像(2)
別名:
3β,5α,6β-trihydroxycholestane (d7)
Empirical Formula (Hill Notation):
C27H41D7O3
CAS番号:
127684-07-5
分子量:
427.71
NACRES:
NA.25

詳細

cholestane-3β,5α,6β-triol-d7

アッセイ

>99% (TLC)

形状

powder

包装

pkg of 1 × 1 mg (700055P-1mg)
pkg of 1 × 5 mg (700055P-5mg)

manufacturer/tradename

Avanti Polar Lipids

輸送温度

dry ice

保管温度

−20°C

SMILES string

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)[C@@]3(O)[C@H](O)C2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

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当該品目
700054P700013P700012P
5α,6β-dihydroxycholestanol-d7 Avanti Polar Lipids

Avanti

700055P

5α,6β-dihydroxycholestanol-d7

5α,6β-dihydroxycholestanol Avanti Polar Lipids

Avanti

700054P

5α,6β-dihydroxycholestanol

15β-hydroxycholestane Avanti Polar Lipids

Avanti

700013P

15β-hydroxycholestane

15α-hydroxycholestane Avanti Polar Lipids

Avanti

700012P

15α-hydroxycholestane

form

powder

form

powder

form

powder

form

powder

packaging

pkg of 1 × 1 mg (700055P-1mg), pkg of 1 × 5 mg (700055P-5mg)

packaging

pkg of 1 × 25 mg (700054P-25mg), pkg of 1 × 5 mg (700054P-5mg)

packaging

pkg of 1 × 5 mg (700013P-5mg)

packaging

pkg of 1 × 5 mg (700012P-5mg)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

manufacturer/tradename

Avanti Polar Lipids 700055P

manufacturer/tradename

Avanti Polar Lipids 700054P

manufacturer/tradename

Avanti Polar Lipids 700013P

manufacturer/tradename

Avanti Polar Lipids 700012P

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

詳細

5α,6β-dihydroxycholestanol is a structural derivative of cholesterol and is an abundant oxysterols. 5α,6β-dihydroxycholestanol-d7 is a deuterated form of 5α,6β-dihydroxycholestanol.

アプリケーション

5α,6β-dihydroxycholestanol-d7 has been used as an analyte in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis based multiple reaction monitoring (MRM) studies and as an internal standard in tandem mass spectrometry (MS/MS) for analysis of plasma samples.

生物化学的／生理学的作用

5α,6β-dihydroxycholestanol (5α,6β-diOH-Chol) or cholestane-3β,5α,6β-triol (C-triol) levels are elevated along with 7-ketocholesterol in Niemann-Pick type C (NP-C) disease and is a key biomarkers for detection. It has ,neuroprotective functionality and may elicit protection against neuronal injury during ischemia.

包装

5 mL Amber Glass Screw Cap Vial (700055P-1mg)
5 mL Amber Glass Screw Cap Vial (700055P-5mg)

よく一緒に購入される製品

製品番号
詳細
価格

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

No data available

引火点(℃)

No data available

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製品番号
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25G
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705578-5MG-PW

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1000309185

入力例：1.000309185)

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Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

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  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

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COAをリクエストする

Haiyan Hu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11426-11438 (2014-08-22)
Overstimulation of NMDA-type glutamate receptors is believed to be responsible for neuronal death of the CNS in various disorders, including cerebral and spinal cord ischemia. However, the intrinsic and physiological mechanisms of modulation of these receptors are essentially unknown. Here
Sara Boenzi et al.
Journal of lipid research, 57(3), 361-367 (2016-01-07)
Oxysterols are intermediates of cholesterol metabolism and are generated from cholesterol via either enzymatic or nonenzymatic pathways under oxidative stress conditions. Cholestan-3β,5α,6β-triol (C-triol) and 7-ketocholesterol (7-KC) have been proposed as new biomarkers for the diagnosis of Niemann-Pick type C (NP-C)
Ren Sheng et al.
Nature communications, 5, 4393-4393 (2014-07-16)
Wnt proteins control diverse biological processes through β-catenin-dependent canonical signalling and β-catenin-independent non-canonical signalling. The mechanisms by which these signalling pathways are differentially triggered and controlled are not fully understood. Dishevelled (Dvl) is a scaffold protein that serves as the
Glynis Klinke et al.
Clinical biochemistry, 48(9), 596-602 (2015-03-31)
Niemann-Pick type C (NP-C) is a rare progressive neurodegenerative lipid storage disorder with heterogeneous clinical presentation and challenging diagnostic procedures. Recently oxysterols have been reported to be specific biomarkers for NP-C but knowledge on the intra-individual variation and on reference
M Voorink-Moret et al.
Molecular genetics and metabolism, 123(2), 76-84 (2018-01-02)
In patients suspected of a lipid storage disorder (sphingolipidoses, lipidoses), confirmation of the diagnosis relies predominantly on the measurement of specific enzymatic activities and genetic studies. New UPLC-MS/MS methods have been developed to measure lysosphingolipids and oxysterols, which, combined with

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