Merck

700070P

Avanti

trihydroxycholestanoic acid

Avanti Polar Lipids

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別名:
3α,7α,12α-trihydroxycholestanoic acid
Empirical Formula (Hill Notation):
C27H46O5
CAS番号:
分子量:
450.65
NACRES:
NA.25

アッセイ

>99% (TLC)

形状

powder

包装

pkg of 1 × 1 mg (700070P-1mg)

manufacturer/tradename

Avanti Polar Lipids

輸送温度

dry ice

保管温度

−20°C

InChI

1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1

InChI key

CNWPIIOQKZNXBB-VCVMUKOKSA-N

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当該品目
700027P700228P700189P
trihydroxycholestanoic acid Avanti Polar Lipids

Avanti

700070P

trihydroxycholestanoic acid

form

powder

form

powder

form

powder

form

powder

packaging

pkg of 1 × 1 mg (700070P-1mg)

packaging

pkg of 1 × 1 mg (700027P-1mg)

packaging

package of 1 × 1 mg

packaging

package of 1 × 1 mg

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

manufacturer/tradename

Avanti Polar Lipids

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

詳細

Trihydroxycholestanoic acid (THCA) is an oxidative metabolite of cholesterol and a precursor to bile acids. Very long-chain acyl-CoA synthetase (VLCS) associated with endoplasmic reticulum and peroxisomes activates THCA, the C27 bile acid intermediate.

アプリケーション

Trihydroxycholestanoic acid has been used as a sterol to test its reactivity with human mincle protein.

生物化学的/生理学的作用

Trihydroxycholestanoic acid (THCA) and dihydroxycholestanoic (DHCA) accumulation is observed in Zellweger syndrome and cholestatic liver disease. The synthesis of (25R)-isomer of DHCA and THCA is favored by mitochondrial 27-hydroxylase.

包装

5 mL Amber Glass Screw Cap Vial (700070P-1mg)

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

No data available

引火点(℃)

No data available


Certificates of Analysis (COA)

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製品番号
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25G
容量/数量

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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

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COAをリクエストする

S Ferdinandusse et al.
Journal of lipid research, 42(1), 137-141 (2001-02-13)
We identified a new peroxisomal disorder caused by a deficiency of the enzyme alpha-methylacyl-coenzyme A (CoA) racemase. Patients with this disorder show elevated plasma levels of pristanic acid and the bile acid intermediates di- and trihydroxycholestanoic acid (DHCA and THCA)
James O'Byrne et al.
The Journal of biological chemistry, 278(36), 34237-34244 (2003-06-18)
Bile acid-CoA:amino acid N-acyltransferase (BACAT) catalyzes the conjugation of bile acids to glycine and taurine for excretion into bile. By use of site-directed mutagenesis and sequence comparisons, we have identified Cys-235, Asp-328, and His-362 as constituting a catalytic triad in
Ryoko Kiyotake et al.
The Journal of biological chemistry, 290(42), 25322-25332 (2015-08-25)
C-type lectin receptors (CLRs) are an emerging family of pattern recognition receptors that recognizes pathogens or damaged tissue to trigger innate immune responses. However, endogenous ligands for CLRs are not fully understood. In this study, we sought to identify an

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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