Merck
すべての画像(2)

資料

857395P

Avanti

GT-11

N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide, powder

すべての画像(2)
別名:
C8-CPPC, C8-cyclopropenylceramide, GT-11 dihydroceramide desaturase inhibitor
Empirical Formula (Hill Notation):
C28H53NO3
CAS番号:
649767-83-9
分子量:
451.73
NACRES:
NA.25

アッセイ

>99% (TLC)

形状

powder

包装

pkg of 1 × 1 mg (857395P-1mg)

manufacturer/tradename

Avanti Polar Lipids 857395P

lipid type

bioactive lipids
sphingolipids

輸送温度

dry ice

保管温度

−20°C

SMILES string

CCCCCCCCCCCCCCC1=C(C1)[C@@H](O)[C@@H](NC(CCCCCCC)=O)CO

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当該品目
860430P860455P850482P
GT-11 N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide, powder

Avanti

857395P

GT-11

C8 Galactosyl(α) Ceramide (d18:1/8:0) D-galactosyl-α-1,1′ N-octanoyl-D-erythro-sphingosine, powder

Avanti

860430P

C8 Galactosyl(α) Ceramide (d18:1/8:0)

N-C12-deoxysphingosine N-lauroyl-1-deoxysphingosine (m18:1/12:0), powder

Avanti

860455P

N-C12-deoxysphingosine

16:0-18:0 (11-12BR) PC 1-palmitoyl-2-(11,12-dibromo)stearoyl-sn-glycero-3-phosphocholine, powder

Avanti

850482P

16:0-18:0 (11-12BR) PC

form

powder

form

powder

form

powder

form

powder

packaging

pkg of 1 × 1 mg (857395P-1mg)

packaging

pkg of 1 × 5 mg (860430P-5mg)

packaging

pkg of 1 × 1 mg (860455P-1mg), pkg of 1 × 5 mg (860455P-5mg)

packaging

pkg of 1 × 10 mg (850482P-10mg)

manufacturer/tradename

Avanti Polar Lipids 857395P

manufacturer/tradename

Avanti Polar Lipids 860430P

manufacturer/tradename

Avanti Polar Lipids 860455P

manufacturer/tradename

Avanti Polar Lipids 850482P

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

詳細

GT-11 is also termed as C8-cyclopropenylceramide or C8-CPPC.

生物化学的／生理学的作用

GT-11 is an inhibitor of dihydroceramides (DHCer) desaturase activity.

包装

5 mL Amber Glass Screw Cap Vial (857395P-1mg)

保管分類コード

11 - Combustible Solids

Certificates of Analysis (COA)

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Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich製品

  • もしTO09019TOなどのロット番号を見つけた場合は、最初の2文字を除いたロット番号09019TOを入力します。

  • もし05427ES-021などの充てんコード付きロット番号を見つけた場合は、充てんコードの-021を除いたロット番号05427ESを入力します。

  • もしSTBB0728K9などの充てんコード付きロット番号を見つけた場合は、充てんコードのK9を除いたロット番号STBB0728を入力します。

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COAをリクエストする

Gemma Triola et al.
Molecular pharmacology, 66(6), 1671-1678 (2004-09-17)
Dihydroceramide desaturase catalyzes the conversion of the innocuous precursor dihydroceramide into a highly bioactive product ceramide. We studied the effect of N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11), the first inhibitor of this enzyme, in primary cultured cerebellar neurons. Although desaturase was efficiently inhibited (IC50
Inhibition of sphingolipid metabolism enhances resveratrol chemotherapy in human gastric cancer cells
Shin K, et al.
Biomolecules & Therapeutics, 20(5), 470-470 (2012)
Bioactive sphingolipids: An overview on ceramide, ceramide 1-phosphate dihydroceramide, sphingosine, sphingosine 1-phosphate
Handbook of Neurochemistry and Molecular Neurobiology:Neural Lipids, 373-383 (2010)
Pau Muñoz-Guardiola et al.
Autophagy, 17(6), 1349-1366 (2020-05-14)
ABTL0812 is a first-in-class small molecule with anti-cancer activity, which is currently in clinical evaluation in a phase 2 trial in patients with advanced endometrial and squamous non-small cell lung carcinoma (NCT03366480). Previously, we showed that ABTL0812 induces TRIB3 pseudokinase

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