860521P

C16 Galactosyl(β) Ceramide (d18:1/16:0)

Avanti Polar Lipids 860521P, powder

• 別名: D-galactosyl-β-1,1′ N-palmitoyl-D-erythro-sphingosine
• Empirical Formula (Hill Notation): C₄₀H₇₇NO₈
• CAS番号: 34324-89-5
• 分子量: 700.04
• NACRES: NA.25

特性

• 形状: powder
• 包装: pkg of 1 × 5 mg (860521P-5mg)
• manufacturer/tradename: Avanti Polar Lipids 860521P
• lipid type: sphingolipids
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES string: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O
• InChI: 1S/C40H77NO8/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(43)33(32-48-40-39(47)38(46)37(45)35(31-42)49-40)41-36(44)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,33-35,37-40,42-43,45-47H,3-26,28,30-32H2,1-2H3,(H,41,44)/b29-27+/t33?,34-,35-,37+,38+,39-,40+/m1/s1
• InChI key: VJLLLMIZEJJZTE-BUDJNAOESA-N

詳細

詳細

D-galactosyl-β-1,1′N-palmitoyl-D-erythro-sphingosine or C16 Galactosyl(β) ceramide consists of a cer(d18:1/16:0) core structure to which a sugar molecule and galactose, is linked through β-glycosidic linkage. Galactosyl ceramide is a complex glycosphingolipid, which contains a single galactose residue linked to ceramide. It is a major constituent of the myelin sheath. Galactosyl ceramide is found majorly on the surface of colonic epithelial cells, vaginal epithelium and primary mammary epithelial cells.

アプリケーション

C16 Galactosyl(β) ceramide (d18:1/16:0) has been used as a lipid standard for its quantification using differential ion mobility spectrometry (DMS) coupled with liquid chromatography in electrospray ionization tandem mass spectrometry (LC-ESI-DMS-MS/MS) in human plasma. It has also been used for the preparation of lipid dispersions. It may be used as a glycosphingolipid (GSL) standard to optimize its characteristic fragmentation using electrospray ionization (ESI) triple quadrupole tandem mass spectrometry (MS/MS). It may also be used to study the structural changes caused by ultraviolet (UVA)?induced photooxidation of galactosyl (GalCer) by electrospray ionization mass spectrometry (ESI?MS) analysis.

生物化学的／生理学的作用

Galactosyl ceramide is crucial for normal myelin function and stability. It prevents epithelial cell-human immunodeficiency virus 1 (HIV-1) virion binding.

包装

5 mL Amber Glass Screw Cap Vial (860521P-5mg)

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable